263400-68-6

Basic information

• Product Name: 4-Chloro-6-methoxy-quinazolin-7-ol
• Synonyms: 4-Chloro-6-methoxy-quinazolin-7-ol;4-Chloro-7-hydroxy-6-Methoxyquinazoline;4-Chloro-7-hydroxy-6-Meth...;4-chloro-6-methoxy-3H-quinazolin-7-one
• CAS NO: 263400-68-6
• Molecular Formula: C₉H₇ClN₂O₂
• Molecular Weight: 210.61708
• Mol File: 263400-68-6.mol
• Article Data: 23

Chemical Properties

• Boiling Point: 379.4±37.0 °C(Predicted)
• Appearance: /
• Density: 1.458±0.06 g/cm3(Predicted)
• PKA: 7.07±0.40(Predicted)
• CAS DataBase Reference: 4-Chloro-6-methoxy-quinazolin-7-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Chloro-6-methoxy-quinazolin-7-ol(263400-68-6)
• EPA Substance Registry System: 4-Chloro-6-methoxy-quinazolin-7-ol(263400-68-6)

Safety Data

• Hazardous Substances Data: 263400-68-6(Hazardous Substances Data)

Usage

General Description

4-Chloro-6-methoxy-quinazolin-7-ol is a chemical compound with the molecular formula C9H7ClN2O2. It is a derivative of quinazoline and is commonly used in pharmaceutical research and drug development. 4-Chloro-6-methoxy-quinazolin-7-ol has been found to exhibit potential anti-cancer and anti-inflammatory properties, making it a promising candidate for the treatment of various diseases. Its unique chemical structure and biological activities make it a valuable target for further investigation and potential therapeutic applications.

Upstream product

• 848092-84-2 methyl 2-amino-4-hydroxy-5-methoxybenzoate 
• 162012-72-8 7-hydroxy-6-methoxy-3,4-dihydroquinazolin-4-one 
• 179688-01-8 7-(benzyloxy)-6-methoxyquinazolin-4(3H)-one 
• 61032-42-6 methyl 2-amino-4-(benzyloxy)-5-methoxybenzoate 
• 61032-41-5 methyl 4-(benzyloxy)-5-methoxy-2-nitrobenzoate 
• 56441-97-5 methyl 4-(benzyloxy)-3-methoxybenzoate 
• 3943-74-6 4-hydroxy-3-methoxybenzoic acid methyl ester 
• 1236153-08-4 methyl 2-amino-5-methoxy-4-(prop-2-ynyloxy)benzoate 
• 1236153-05-1 5-methoxy-2-nitro-4-(prop-2-yn-1-yloxy)benzoic acid methyl ester 
• 1236153-10-8 6-methoxy-7-(prop-2-ynyloxy)quinazolin-4(3H)-one 
• 179688-03-0 4-chloro-6-methoxyquinazolin-7-yl acetate 
• 894426-99-4 1-(2-aminobenzothiazol-6-yl)-3-(4-chloro-3-trifluoromethylphenyl)urea 
• 179688-02-9 7-acetoxy-6-methoxy-3,4-dihydroquinazolin-4-one 

Downstream Products

• 1622396-50-2 C₃₂H₃₈N₆O₅ 
• 264208-72-2 4-chloro-6-methoxy-7-[(1'-methylpiperidin-4'-yl)methoxy]-quinazoline 
• 196194-45-3 4-chloro-6-methoxy-7-(2-methoxyethoxy)quinazoline 
• 1622343-17-2 C₂₆H₂₆ClN₅O₇ 
• 1622343-33-2 C₂₉H₂₈ClFN₄O₆ 
• 1622396-81-9 C₂₁H₂₂ClN₃O₅ 
• 1622343-45-6 C₃₄H₃₅ClFN₅O₆ 
• 1622396-73-9 C₂₇H₂₄ClFN₄O₆ 
• 1622396-72-8 C₂₉H₂₈ClFN₄O₆ 
• 1622343-29-6 C₃₁H₃₃ClN₆O₇ 
• 1622396-71-7 C₂₄H₂₂ClN₅O₇ 
• 1622396-70-6 C₂₆H₂₆ClN₅O₇ 
• 1622396-69-3 C₂₁H₂₂ClN₃O₅ 
• 199327-69-0 4-chloro-6-methoxy-7-(3-(pyrrolidin-1-yl)propoxy)quinazoline 

Relevant articles and documents

THERAPEUTIC COMPOUNDS AND USES THEREOF

Described herein are compounds of Formula (I) or Formula (VI), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Also provided are particles (e.g., nanoparticles) comprising compounds of Formula (I) or Formula (VI) and pharmaceutical compositions thereof that are mucus penetrating. Methods of using the compounds or pharmaceutical compositions thereof for treating diseases are also provided.

STEROIDAL ANTI-HORMONE HYBRIDS

Disclosed are novel compounds and compositions for inhibition of androgen and estrogen receptor signaling, methods for inhibiting androgen signaling, methods for inhibiting estrogen signaling, methods for inhibiting the interaction between a co-regulatory protein and an androgen or estrogen receptor, and methods for treating cancer.

Thiazole Analogues and Uses Thereof

Compounds of formula (I) and salts and physiologically functional derivatives thereof, wherein R2 is attached at the 4- or 5-position of the thiazole ring and is hydrogen, alkyl, halogen, cyano, alkoxy, haloalkoxy, or alkylamino; X independently represents a divalent linkage group selected from S, O, NR4, SO, or SO2; R4 is hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, or heterocyclyl; R1 is attached at the 4- or 5-position of the thiazole ring and independently represents a group of formula (II): ?wherein the dotted line represents a single or double bond; * indicates the point of attachment to the thiazole ring; and n is 1, 2, or 3. Also disclosed are pharmaceutical compositions comprising the above compounds and method of treatments for cancer and other diseases.