263409-95-6

Basic information

• Product Name: 4-(4-fluorophenyl)-1,4-diazepane-1-carboxylic acid tert-butyl ester
• Synonyms: 4-(4-fluorophenyl)-1,4-diazepane-1-carboxylic acid tert-butyl ester
• CAS NO: 263409-95-6
• Molecular Weight: 294.369
• Mol File: 263409-95-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-(4-fluorophenyl)-1,4-diazepane-1-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-fluorophenyl)-1,4-diazepane-1-carboxylic acid tert-butyl ester(263409-95-6)
• EPA Substance Registry System: 4-(4-fluorophenyl)-1,4-diazepane-1-carboxylic acid tert-butyl ester(263409-95-6)

Safety Data

• Hazardous Substances Data: 263409-95-6(Hazardous Substances Data)

Upstream product

• 112275-50-0 tert-butyl 1,4-diazepine-1-carboxylate 
• 460-00-4 1-Bromo-4-fluorobenzene 

Downstream Products

• 263409-96-7 1-(4-fluorophenyl)-1,4-diazepane hydrochloride salt 
• 868064-37-3 (Z)-2-cyano-3-[4-(4-fluorophenyl)-1,4-diazepan-1-yl]but-2-enethioamide 
• 868064-36-2 3-amino-4-[4-(4-fluorophenyl)-1,4-diazepan-1-yl]thieno[2,3-b]pyridine-2-carboxamide 
• 751468-47-0 1-(4-fluorophenyl)-1,4-diazepane 

Relevant articles and documents

PYRROLE mTORC INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same.

Discovery and structure-activity relationship of thienopyridine derivatives as bone anabolic agents

A cell-based assay was performed for the discovery of novel bone anabolic agents. Alkaline phosphatase (ALPase) activity of ST2 cells was utilized as an indicator of osteoblastic differentiation, and thienopyridine derivative 1 was identified as a hit compound. 3-Aminothieno[2,3-b]pyridine-2-carboxamide was confirmed to be a necessary core structure for the enhancement of ALPase activity, and then optimization of the C4-substituent on the thienopyridine ring was carried out. Introduction of cyclic amino groups to the C4-position of the thienopyridine ring improved the activity. Especially, N-phenyl-homopiperazine derivatives were found to be strong enhancers of ALPase among this new series. Furthermore, 3-amino-4-(4-phenyl-1,4-diazepan-1-yl)thieno[2,3-b]pyridine-2- carboxamide (15k) was orally administered to ovariectomized (OVX) rats over 6 weeks for evaluating the effects on areal bone mineral density (aBMD), and statistically significant improvements in aBMD were observed from the dosage of 10 mg/kg/day.