26345-15-3

Basic information

• Product Name: 5,6,7,8-Tetrahydroisoquinolin-1(2H)-one
• Synonyms: 5,6,7,8-Tetrahydroisoquinolin-1(2H)-one;5,6,7,8-tetrahydroisoquinolin-1-ol
• CAS NO: 26345-15-3
• Molecular Formula: C₉H₁₁NO
• Molecular Weight: 149.18974
• Mol File: 26345-15-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 202-203 °C(Solv: ethyl ether (60-29-7); ligroine (8032-32-4))
• Boiling Point: 402.4±18.0 °C(Predicted)
• Appearance: /
• Density: 1.13±0.1 g/cm3(Predicted)
• PKA: 13.13±0.20(Predicted)
• CAS DataBase Reference: 5,6,7,8-Tetrahydroisoquinolin-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6,7,8-Tetrahydroisoquinolin-1(2H)-one(26345-15-3)
• EPA Substance Registry System: 5,6,7,8-Tetrahydroisoquinolin-1(2H)-one(26345-15-3)

Safety Data

• Hazardous Substances Data: 26345-15-3(Hazardous Substances Data)

Upstream product

• 855651-19-3 1-ethoxy-5,6,7,8-tetrahydro-isoquinoline 
• 491-30-5 1-isoquinolone 
• 1297284-55-9 methyl 2-(5-fluoro-3-iodo-2-methyl-1H-indol-1-yl)acetate 
• 1297284-54-8 5-fluoro-3-iodo-2-methyl-1H-indole 
• 399-72-4 5-fluoro-2-methyl-1H-indole 
• 26278-74-0 3,4-dihydro-3-phenyl-1(2H)-isoquinolinone 
• 491-30-5 1-hydroxyisoquinoline 
• 19493-44-8 1-chloroisoquinoline 
• 858194-24-8 1-ethoxy-5,6,7,8-tetrahydro-[4]isoquinolylamine 
• 59050-59-8 4-bromo-1-ethoxy-isoquinoline 
• 59050-62-3 1-ethoxy-[4]isoquinolylamine 
• 3749-21-1 4-bromoisoquinoline N-oxide 
• 66728-98-1 4-bromo-1-chloroisoqionoline 
• 66728-96-9 1-ethoxyisoquinoline 

Downstream Products

• 861136-91-6 1-[3-(1-methoxy-5,6,7,8-tetrahydro-isoquinolin-4-ylamino)-phenyl]-ethanone 
• 861136-92-7 (3-methanesulfonyl-phenyl)-(1-methoxy-5,6,7,8-tetrahydro-isoquinolin-4-yl)-amine 
• 36556-06-6 5,6,7,8-tetrahydroisoquinoline 
• 1297276-94-8 2-(3-(2-benzyl-1-oxo-1,2,5,6,7,8-hexahydroisoquinolin-4-yl)-5-fluoro-2-methyl-1H-indol-1-yl)acetic acid 
• 1297284-56-0 2-benzyl-4-iodo-5,6,7,8-tetrahydroisoquinolin-1(2H)-one 
• 1297284-57-1 2-benzyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6,7,8-tetrahydroisoquinolin-1(2H)-one 
• 1590402-82-6 C₁₉H₁₉N₃O 
• 1590402-79-1 2-phenyl-4-methyl-5,6,7,8-tetrahydrocyclohexa[c]pyridin-1(2H)-one 
• 1590409-66-7 C₁₅H₁₄BrNO 
• 444898-52-6 C₃₅H₃₁NO₈ 

Relevant articles and documents

A Chiral Phenanthroline Ligand with a Hydrogen-Bonding Site: Application to the Enantioselective Amination of Methylene Groups

A silver-catalyzed amination is reported that occurs at the aliphatic C3-substituent of various quinolones and pyridones. The C-H amination reaction proceeded with high site-and enantioselectivity (14 examples, 83-97% ee). The key to its success is the use of a chiral phenanthroline ligand that is attached via an ethynyl linker to the 8-position of octahydro-1H-4,7-methanoisoindol-1-one. AgPF6 (10 mol %) served as the silver source, PhI.NNs as the nitrene precursor, and 1,10-phenanthroline as the coligand. The reaction outcome can be understood by assuming a nitrene C-H insertion within a hydrogen-bonded silver complex in which a single C-H bond is exposed to the catalytic reaction center.

ANTI-FIBROTIC PYRIDINONES

Disclosed are pyridinone compounds, method for preparing these compounds, and methods for treating fibrotic disorders.

INDOLE BASED RECEPTOR CRTH2 ANTAGONISTS

Disclosed are compounds of Formula (I): which are useful as antagonists of the CRTH2 receptors. Pharmaceutical compositions containing compounds of Formula (I) and the use of compounds of Formula (I) to treat diseases or disorders that are responsive to inhibition of the binding of endogenous ligands to the CRTH2 receptor are also disclosed. Methods for preparing and using these compounds are further described.