26366-02-9Relevant academic research and scientific papers
TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS
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Page/Page column 29, (2011/04/25)
The invention relates to tetrazole compounds of formula (I) wherein X, Y, Z, R1, R2 and R3 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.
TETRAZOLE COMPOUNDS AS OREXIN RECEPTOR ANTAGONISTS
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Page/Page column 70, (2010/01/07)
The invention relates to tetrazole compounds of formula (I) wherein X, Y, Z, R1, R2 and R3 are as described in the description; to pharmaceutically acceptable salts thereof, and to the use of such compounds use as medicaments, especially as orexin receptor antagonists.
1,5-SUBSTITUTED TETRAZOLES AS THERAPEUTIC COMPOUNDS
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Page/Page column 86, (2010/11/26)
The present invention pertains to certain 1,5-substituted-1H-tetrazole compounds that, inter alia, inhibit 11β- hydroxysteroid dehydrogenase type 1 (11β-HSD1). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, bothin vitro and in vivo, to inhibit 11β-hydroxysteroid dehydrogenase type 1; to treat conditions that are ameliorated by the inhibition of 11β-hydroxysteroid dehydrogenase type 1; to treat the metabolic syndrome, which includes conditions such as type 2 diabetes and obesity, and associated disorders including insulin resistance, hypertension, lipid disorders and cardiovascular disorders such as ischaemic (coronary) heart disease; to treat CNS conditions such as mild cognitive impairment and early dementia, including Alzheimer's disease; etc.
