263711-70-2Relevant academic research and scientific papers
Synthesis and biological evaluation of bryostatin analogues: The role of the A-ring
Wender, Paul A.,Lippa, Blaise
, p. 1007 - 1011 (2007/10/03)
The first biologically active member and a key intermediate of a new family of simplified bryostatin analogues are synthesized through an optimized esterification-macrotransacetalization strategy. This family incorporates both an ester linkage between C5 and C9 in addition to a C9 t- butyl substituent to mimic the bryostatin A-ring. Importantly, a free C7 alcohol is revealed late in the synthesis, allowing access to numerous C7 derivatized analogues. (C) 2000 Elsevier Science Ltd.
