263711-96-2Relevant academic research and scientific papers
Ready access to sialylated oligosaccharide donors
Mehta, Seema,Gilbert, Michel,Wakarchuk, Warren W.,Whitfield, Dennis M.
, p. 751 - 753 (2000)
(figure presented) Numerous glycoconjugates contain the disaccharide Neu5Acα(2→S)DGalp. An efficient way to incorporate this disaccharide into synthetic glycoconjugates is to develop a disaccharide building block. This communication reports a chemoenzymatic route to such a building block which requires as few as four steps. Some examples using more chemical steps are also presented, which increase the flexibility. These disaccharide donors were used to prepare synthetic trisaccharides.
