263769-26-2Relevant articles and documents
Synthesis, molecular modeling, and biological studies of novel piperidine-based analogues of cocaine: Evidence of unfavorable interactions proximal to the 3α-position of the piperidine ring
Petukhov, Pavel A.,Zhang, Jianrong,Wang, Cheng Z.,Ye, Yan Ping,Johnson, Kenneth M.,Kozikowski, Alan P.
, p. 3009 - 3018 (2007/10/03)
A qualitative model for the binding pocket proximal to the 3α-substituent of the piperidine-based monoamine transporter ligands was proposed and tested. Based on this model, a new series of druglike 3α-modified piperidine-based analogues of cocaine were d
Analogs of cocaine
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, (2008/06/13)
The invention provides a compound of formula (I): STR1wherein R 1, R 2, R 3, and Y have any of the meanings defined in the specification; as well a pharmaceutical composition comprising a compound of formula I; intermediates and methods useful for preparing a compound of formula I; and therapeutic methods for treating drug addiction, Parkinson''s disease or depression comprising administering a compound of formula I, to a mammal in need of such treatment.