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Usage

Uses

Used in Pharmaceutical and Psychoactive Substances Synthesis:
2-(3-METHOXY-PHENOXY)-ETHYLAMINEHYDROCHLORIDE is used as a precursor in the synthesis of various pharmaceuticals and psychoactive substances. Its unique chemical structure allows it to be a key component in the production of these compounds.
Used in Neuropharmacology Research:
In the field of neuropharmacology, 2-(3-METHOXY-PHENOXY)-ETHYLAMINEHYDROCHLORIDE is used as a research compound for studying its interactions with neurotransmitter receptors. This helps in understanding its potential effects on the central nervous system and its possible applications in the treatment of neurological disorders.
Used in Medicinal Chemistry:
2-(3-METHOXY-PHENOXY)-ETHYLAMINEHYDROCHLORIDE is utilized in medicinal chemistry for the development of new drugs and therapeutic agents. Its ability to influence the central nervous system makes it a valuable candidate for the creation of medications targeting neurological conditions.
Used in Organic Chemistry:
In the realm of organic chemistry, 2-(3-METHOXY-PHENOXY)-ETHYLAMINEHYDROCHLORIDE is employed as a reagent or intermediate in various chemical reactions. Its versatility in forming different chemical bonds and its stability make it a useful compound for organic synthesis.
Used in Drug Development:
2-(3-METHOXY-PHENOXY)-ETHYLAMINEHYDROCHLORIDE is used in drug development as a potential candidate for the creation of new medications. Its interactions with neurotransmitter receptors and its influence on the central nervous system make it a promising substance for the development of drugs targeting neurological and psychiatric disorders.

Upstream product

• 586416-77-5 N-[2-(3-methoxyphenoxy)ethyl]acetamide 
• 150-19-6 O-methylresorcine 
• 1329611-57-5 C₁₄H₂₁NO₄ 

Downstream Products

• 586416-79-7 ethyl 2-[2-({[2-(3-methoxyphenoxy)ethyl]amino}carbonyl)phenyl]ethylcarbonate 
• 742055-21-6 5-[2-(2-chloroethyl)phenyl]-8-methoxy-2,3-dihydro-1,4-benzoxazepine hydrochloride 
• 586416-78-6 2-(2-hydroxyethyl)-N-[2-(3-methoxyphenoxy)ethyl]benzamide 

Relevant academic research and scientific papers

Discovery of Potent, Reversible, and Competitive Cruzain Inhibitors with Trypanocidal Activity: A Structure-Based Drug Design Approach

A virtual screening conducted with nearly 4?000?000 compounds from lead-like and fragment-like subsets enabled the identification of a small-molecule inhibitor (1) of the Trypanosoma cruzi cruzain enzyme, a validated drug target for Chagas disease. Subsequent comprehensive structure-based drug design and structure-activity relationship studies led to the discovery of carbamoyl imidazoles as potent, reversible, and competitive cruzain inhibitors. The most potent carbamoyl imidazole inhibitor (45) exhibited high affinity with a Ki value of 20 nM, presenting both in vitro and in vivo activity against T. cruzi. Furthermore, the most promising compounds reduced parasite burden in vivo and showed no toxicity at a dose of 100 mg/kg. These carbamoyl imidazoles are structurally attractive, nonpeptidic, and easy to prepare and synthetically modify. Finally, these results further advance our understanding of the noncovalent mode of inhibition of this pharmaceutically relevant enzyme, building strong foundations for drug discovery efforts.

Dopamine/serotonin receptor ligands VI. Dibenz[gj]-1-oxa-4-azacycloundecene and dibenz[d,g]-2-azacycloundecene: Synthesis of two new heterocyclic ring systems as potential ligands for dopamine receptor subtypes

2-(2-Hydroxyethyl)-N-[2-phenoxyethyl]benzamides and 2-(2-hydroxyethyl)-N-[2-phenylpropyl]benzamides have been prepared from 2-phenoxyethyl- or 2-phenylpropylamines and isochroman-1-one. Applying Bischler-Napieralski reaction, a tetracyclic isoquinolino[2,

5-HT7 receptor antagonists

Amino-pyrimidine and amino-triazine derivatives having 5-HT7 antagonist activity for the treatment of sleeping disorders, depression, schizophrenia, anxiety, obsessive compulsive disorders, circadian rhythm disorders, ocular disorders and/or ce