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263842-98-4

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  • 3-PYRIDINESULFONIC ACID, 4-[[5,6-DIHYDRO-4-HYDROXY-6-(1-METHYLETHYL)-2-OXO-6-(2-PHENYLETHYL)-2H-PYRAN-3-YL]THIO]-5-(1,1-DIMETHYLETHYL)-2-METHYLPHENYL ESTER

    Cas No: 263842-98-4

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263842-98-4 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 263842-98-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,3,8,4 and 2 respectively; the second part has 2 digits, 9 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 263842-98:
(8*2)+(7*6)+(6*3)+(5*8)+(4*4)+(3*2)+(2*9)+(1*8)=164
164 % 10 = 4
So 263842-98-4 is a valid CAS Registry Number.

263842-98-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name [5-tert-butyl-4-[[4-hydroxy-6-oxo-2-(2-phenylethyl)-2-propan-2-yl-3H-pyran-5-yl]sulfanyl]-2-methylphenyl] pyridine-3-sulfonate

1.2 Other means of identification

Product number -
Other names (+-)-3-Pyridinesulfonic acid,4-((5,6-dihydro-4-hydroxy-6-(1-methylethyl)-2-oxo-6-(2-phenylethyl)-2H-pyran-3-yl)thio)-5-(1,1-dimethylethyl)-2-methylphenyl ester

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:263842-98-4 SDS

263842-98-4Downstream Products

263842-98-4Relevant articles and documents

5,6-Dihydropyran-2-ones possessing various sulfonyl functionalities: Potent nonpeptidic inhibitors of HIV protease

Boyer, Frederick E.,Vara Prasad,Domagala, John M.,Ellsworth, Edmund L.,Gajda, Christopher,Hagen, Susan E.,Markoski, Larry J.,Tait, Bradley D.,Lunney, Elizabeth A.,Palovsky, Alexander,Ferguson, Donna,Graham, Neil,Holler, Tod,Hupe, Donald,Nouhan, Carolyn,Tummino, Peter J.,Urumov,Zeikus, Eric,Zeikus, Greg,Gracheck, Stephen J.,Sanders, James M.,VanderRoest, Steven,Brodfuehrer, Joanne,Iyer, Krishna,Sinz, Michael,Gulnik, Sergei V.,Erickson, John W.

, p. 843 - 858 (2007/10/03)

On the basis of previous SAR findings and molecular modeling studies, a series of compounds were synthesized which possessed various sulfonyl moieties substituted at the 4-position of the C-3 phenyl ring substituent of the dihydropyran-2-one ring system. The sulfonyl substituents were added in an attempt to fill the additional S3' pocket and thereby produce increasingly potent inhibitors of the target enzyme. Racemic and enantiomerically resolved varieties of selected compounds were synthesized. All analogues in the study displayed decent binding affinity to HIV protease, and several compounds were shown to possess very good antiviral efficacy and safety margins. X-ray crystallographic structures confirmed that the sulfonamide and sulfonate moieties were filling the S3' pocket of the enzyme. However, the additional substituent did not provide improved enzymatic inhibitory or antiviral activity as compared to the resolved unsubstituted aniline. The addition of the sulfonyl moiety substitution does not appear to provide favorable pharamacokinectic parameters. Selected inhibitors were tested for antiviral activity in clinical isolates and exhibited similar antiviral activity against all of the HIV-1 strains tested as they did against the wild-type HIV-1. In addition, the inhibitors exhibited good antiviral efficacies against HIV-1 strains that displayed resistance to the currently marketed protease inhibitors.

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