263846-88-4

Basic information

• Product Name: 1-(2-{5-amino-2-[(4''-pentyloxy-[1,1';4',1'']terphenyl-4-carbonyl)-amino]-pentanoylamino}-3-tert-butoxy-butyryl)-4-tert-butoxy-pyrrolidine-2-carboxylic acid tert-butyl ester
• Synonyms: 1-(2-{5-amino-2-[(4''-pentyloxy-[1,1';4',1'']terphenyl-4-carbonyl)-amino]-pentanoylamino}-3-tert-butoxy-butyryl)-4-tert-butoxy-pyrrolidine-2-carboxylic acid tert-butyl ester
• CAS NO: 263846-88-4
• Molecular Weight: 857.144
• Mol File: 263846-88-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(2-{5-amino-2-[(4''-pentyloxy-[1,1';4',1'']terphenyl-4-carbonyl)-amino]-pentanoylamino}-3-tert-butoxy-butyryl)-4-tert-butoxy-pyrrolidine-2-carboxylic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-{5-amino-2-[(4''-pentyloxy-[1,1';4',1'']terphenyl-4-carbonyl)-amino]-pentanoylamino}-3-tert-butoxy-butyryl)-4-tert-butoxy-pyrrolidine-2-carboxylic acid tert-butyl ester(263846-88-4)
• EPA Substance Registry System: 1-(2-{5-amino-2-[(4''-pentyloxy-[1,1';4',1'']terphenyl-4-carbonyl)-amino]-pentanoylamino}-3-tert-butoxy-butyryl)-4-tert-butoxy-pyrrolidine-2-carboxylic acid tert-butyl ester(263846-88-4)

Safety Data

• Hazardous Substances Data: 263846-88-4(Hazardous Substances Data)

Upstream product

• 263846-85-1 1-{2-[5-benzyloxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-pentanoylamino]-3-tert-butoxy-butyryl}-4-tert-butoxy-pyrrolidine-2-carboxylic acid tert-butyl ester 
• 263846-86-2 1-[2-(2-amino-5-benzyloxycarbonylamino-pentanoylamino)-3-tert-butoxy-butyryl]-4-tert-butoxy-pyrrolidine-2-carboxylic acid tert-butyl ester 
• 3304-51-6 N-carboxybenzyl-L-ornithine 
• 263846-87-3 TerOrn(Z)-Thr(Ot-Bu)-Pro(Ot-Bu) 
• 263846-84-0 (2S,4R)-4-tert-Butoxy-1-[(2S,3R)-3-tert-butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-butyryl]-pyrrolidine-2-carboxylic acid tert-butyl ester 
• 93527-54-9 Hyp(Ot-Bu)Ot-Bu 
• 158937-65-6 2,4,5-trichlorophenyl 4-(4'-pentyloxybiphenyl)benzoate 
• 138775-07-2 N^α-fluorenylmethyloxycarbonyl-N^δ-benzyloxycarbonylornithine 
• 71989-35-0 Fmoc-Thr(tBu)-OH 

Downstream Products

• 263846-91-9 C₇₈H₁₀₃N₉O₁₃ 
• 263846-92-0 1-(2-{5-{[1-(2-amino-3-tert-butoxy-butyryl)-4-azido-pyrrolidine-2-carbonyl]-amino}-2-[(4''-pentyloxy-[1,1';4',1'']terphenyl-4-carbonyl)-amino]-pentanoylamino}-3-tert-butoxy-butyryl)-4-tert-butoxy-pyrrolidine-2-carboxylic acid tert-butyl ester 
• 263846-90-8 (2S,4R)-1-((2S,3R)-2-{(S)-5-[((2S,4S)-4-Azido-pyrrolidine-2-carbonyl)-amino]-2-[(4''-pentyloxy-[1,1';4',1'']terphenyl-4-carbonyl)-amino]-pentanoylamino}-3-tert-butoxy-butyryl)-4-tert-butoxy-pyrrolidine-2-carboxylic acid tert-butyl ester 
• 263846-89-5 C₇₀H₈₈N₈O₁₁ 

Relevant articles and documents

Total synthesis and antifungal evaluation of cyclic aminohexapeptides

The need for new therapies to treat systemic fungal infections continues to rise. Naturally occurring hexapeptide echinocandin B (1) has shown potent antifungal activity via its inhibition of the synthesis of β-1,3 glucan, a key fungal cell wall component. Although this series of agents has been limited thus far based on their physicochemical characteristics, we have found that the synthesis of analogues bearing an aminoproline residue in the 'northwest' position imparts greatly improved water solubility (>5 mg/mL). The synthesis and structure-activity relationships (SAR) based on whole cell and upon in vivo activity of the series of compounds are reported. Copyright (C) 2000 Elsevier Science Ltd.