263848-57-3Relevant academic research and scientific papers
Characterization of mono- and diaminopyrimidine derivatives as novel, nonpeptide gonadotropin releasing hormone (GnRH) receptor antagonists.
Luthin, David R,Hong, Yufeng,Tompkins, Eileen,Anderes, Kenna L,Paderes, Genevieve,Kraynov, Eugenia A,Castro, Mary A,Nared-Hood, Karen D,Castillo, Rosemary,Gregory, Margaret,Vazir, Haresh,May, John M,Anderson, Mark B
, p. 3635 - 3639 (2002)
A novel series of derivatives of mono- and diaminopyrimidines 1 potently displaced binding of a radiolabeled GnRH analogue to human and rat GnRH receptors. Analogues from these series competitively antagonized GnRH-stimulated increases in extracellular acidification in vitro and suppressed GnRH-mediated increases in circulating luteinizing hormone (LH) in castrated rats and testosterone in intact rats. These compounds or their analogues may be useful in treating sex hormone-dependent disease.
