263888-56-8

Basic information

• Product Name: TERT-BUTYL 5-CYANOISOINDOLINE-2-CARBOXYLATE
• Synonyms: TERT-BUTYL 5-CYANOISOINDOLINE-2-CARBOXYLATE;2H-Isoindole-2-carboxylicacid, 5-cyano-1,3-dihydro-, 1,1-dimethylethyl ester
• CAS NO: 263888-56-8
• Molecular Formula: C14H16N2O2
• Molecular Weight: 244.29
• Mol File: 263888-56-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 367.9±42.0 °C(Predicted)
• Appearance: /
• Density: 1.18±0.1 g/cm3(Predicted)
• PKA: -1.75±0.20(Predicted)
• CAS DataBase Reference: TERT-BUTYL 5-CYANOISOINDOLINE-2-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 5-CYANOISOINDOLINE-2-CARBOXYLATE(263888-56-8)
• EPA Substance Registry System: TERT-BUTYL 5-CYANOISOINDOLINE-2-CARBOXYLATE(263888-56-8)

Safety Data

• Hazardous Substances Data: 263888-56-8(Hazardous Substances Data)

Upstream product

• 557-21-1 dicyanozinc 
• 263888-57-9 5-trifluoromethanesulfonyloxy-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester 
• 24424-99-5 di-tert-butyl dicarbonate 
• 1159823-51-4 isoindoline-5-carbonitrile hydrochloride 
• 691-64-5 di-tert-butyl oxalate 
• 149353-71-9 2-(tert-butoxycarbonyl)isoindoline-5-carboxylic acid 
• 368441-44-5 2-(tert-butyl) 5-methyl isoindoline-2,5-dicarboxylate 
• 127168-94-9 methyl 2,3-dihydro-2-(phenylmethyl)-1H-isoindole-5-carboxylate 
• 201940-08-1 5-bromo-1,3-dihydro-isoindole-2-carboxylic acid tert-butyl ester 
• 557-21-1 zinc(II) cyanide 
• 6941-75-9 5-Bromoisoindoline-1,3-dione 
• 127168-84-7 5-bromoisoindoline 
• 685565-18-8 tert-butyl 5-carbamoylisoindoline-2-carboxylate 
• 226070-47-9 tert-butyl 5-hydroxyisoindoline-2-carboxylate 

Downstream Products

• 253801-15-9 5-formyl-1,2-dihydro-isoindole-2-carboxylic acid tertiary butyl ester 
• 263888-58-0 5-cyano-2,3-dihydro-1H-isoindole 
• 437651-10-0 {4-[2-(5-cyano-1,3-dihydro-isoindol-2-yl)-ethyl]-cyclohexyl}-carbamic acid tert-butyl ester 
• 437652-04-5 2-[2-(4-amino-cyclohexyl)-ethyl]-2,3-dihydro-1H-isoindole-5-carbonitrile 

Relevant articles and documents

NOVEL MORPHOLINYL AMINE COMPOUNDS FOR THE TREATMENT OF AUTOIMMUNE DISEASE

The present invention relates to compounds of formula (I), wherein R1, R2 and R3 are as described herein, and their pharmaceutically acceptable salt, enantiomer or diastereomer thereof, and compositions including the compounds and methods of using the compounds.

S1P RECEPTORS MODULATORS

The invention relates to novel compounds that have S1P receptor modulating activity and, preferably, apoptotic activity and/or anti proliferative activity against cancer cells and other cell types. Further, the invention relates to a pharmaceutical comprising at least one compound of the invention for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression, for example, cancer. A further aspect of the invention relates to the use of a pharmaceutical comprising at least one compound of the invention for the manufacture of a medicament for the treatment of diseases and/or conditions caused by or associated with inappropriate S1P receptor modulating activity or expression such as cancer.

Design and synthesis of novel 2,3-dihydro-1H-isoindoles with high affinity and selectivity for the dopamine D3 receptor

Starting from the tetrahydroisoquinoline SB-2770111, a novel series of 5-substituted-2,3-dihydro-1H-isoindoles has been designed. Subsequent optimisation resulted in identification of 19. which has high affinity for the dopamine D3 receptor (pKi 8.3) and ≥ 100-fold selectivity over other aminergic receptors. In rat studies 19 was brain penetrant with an excellent pharmacokinetic profile (oral bioavailability 77%. t1/2 5.2h).