263903-41-9Relevant academic research and scientific papers
Pancreatic α-Amylase inhibition and free radical scavenging activity of substituted pyranochromenone derivatives
Ashok Kumar,Tiwari, Ashok K.,Saidachary,Kishor, Chandan,Kumar, D. Anand,Ali, Zehra,Sridhar,Addlagatta, Anthony,Raju, B. China
, p. 2821 - 2833 (2014)
Pyranochromenone derivatives 3a-d, 6a-j and 2H-chromenones 8a-b were synthesized and screened for their in vitro α-Amylase inhibitory and ABTS?+ [2,2'-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)] free radical scavenging activities. Compounds 3a, 3c, and 6d displayed dual function of ABTS?+ radical scavenging as well as α-Amylase inhibition. Compound 6h was found to be most potent α-Amylase inhibitor in present series of compounds. Docking studies suggest that these compounds occupy active site of the human pancreatic α-Amylase similar to that of acarbose which inhibits enzyme by hydrophobic interactions. These compounds have potential to be developed as therapeutics targeted against diet-induced hyperglycemia in diabetes. Graphical abstract: Series of pyranochromenone derivatives 3a-d, 6a-j, and 8a-b were synthesized, among these compound 6h shown potent intestinal α-Amylase inhibitory activity. Compounds 3a, 3c, and 6d were shown dual properties such as α-Amylase inhibitory and antioxidant activities. These derivatives may serve as a model compounds for design and development of therapeutics based agents.[Figure not available: see fulltext.]
