264121-79-1Relevant academic research and scientific papers
Microwave assisted multi-component synthesis of novel bis(1,4-dihydropyridines) based arenes or heteroarenes
Sanad, Sherif M. H.,Kassab, Refaie M.,Abdelhamid, Ismail A.,Elwahy, Ahmed H. M.
, p. 910 - 924 (2016/07/06)
A synthesis of novel bis-1,4-DHPs was reported. Two possible synthetic approaches for these compounds were investigated. In the first approach the monopodal 1,4-DHPs were used as building blocks for the construction of the target molecules via a simple al
Quinoxalines. Part 13: Synthesis and mass spectrometric study of aryloxymethylquinoxalines and benzo[b]furylquinoxalines
Starke, Ines,Sarodnick, Gerhard,Ovcharenko, Vladimir V.,Pihlaja, Kalevi,Kleinpeter, Erich
, p. 6063 - 6078 (2007/10/03)
A series of new aryloxymethylquinoxalines, benzo[b]- and naphtho[2,1-b]furylquinoxalines, possessing potential biological activity, was prepared, characterized by IR and NMR spectroscopy and their electron ionization (EI) mass spectra studied in detail. The aryloxymethylquinoxalines were obtained by reacting halogenomethylquinoxalines with bifunctional O-nucleophiles. The benzo[b]furylquinoxalines and naphtho[2,1-b] furylquinoxalines were prepared via two routes, which differed in the order of the two cyclization steps involved in the syntheses. The composition of the ions obtained by EI mass spectrometry were determined by accurate mass measurements and the fragmentation pathways clarified by B/E linked scans and collision induced dissociation. The mass spectrometric behaviour of the compounds studied as to the possible loss of OH· radicals proved to be very characteristic.
Synthesis of new benzo-substituted macrocyclic ligands containing quinoxaline subunits
Elwahy, Ahmed H. M.
, p. 897 - 907 (2007/10/03)
The macrocyclic Schiff bases 20-25 were prepared by cyclocondensation of the bis aldehydes 12-15 with the appropriate diaminoalkanes 17-19. Reduction of the latter with NaBH4 afforded the corresponding azacrown ethers 27-30. Heating of the aldehydes 12-16 in refluxing acetic acid afforded the corresponding 2,3-bis(benzofuranyl)quinoxalines 33-37. Nucleophilic reaction of the bis phenols 45-48, 54, 56, 57 with the appropriate dihalo compounds 1, 38 afforded the corresponding macrocyclic diamides 49-52 and 1,ω- bis[quinoxalino(2,3-b)benzoxazepino-13-on-yl]alkanes 60, 61, respectively. (C) 2000 Elsevier Science Ltd.
