264128-49-6

Basic information

• Product Name: 2-Boc-(S)-MethylaMino-3-phenyl-1-propanol
• Synonyms: 2-Boc-(S)-MethylaMino-3-phenyl-1-propanol;(S)-tert-Butyl 2-((1-hydroxy-3-phenylpropan-2-yl)amino)acetate
• CAS NO: 264128-49-6
• Molecular Formula: C₁₅H₂₃NO₃
• Molecular Weight: 265.34802
• Mol File: 264128-49-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 390.0±31.0 °C(Predicted)
• Appearance: /
• Density: 1.076±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 14.63±0.10(Predicted)
• CAS DataBase Reference: 2-Boc-(S)-MethylaMino-3-phenyl-1-propanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Boc-(S)-MethylaMino-3-phenyl-1-propanol(264128-49-6)
• EPA Substance Registry System: 2-Boc-(S)-MethylaMino-3-phenyl-1-propanol(264128-49-6)

Safety Data

• Hazardous Substances Data: 264128-49-6(Hazardous Substances Data)

Upstream product

• 37553-65-4 Boc-N-Me-Phe-OH 
• 66605-57-0 (S)-N-tert-butoxycarbonyl-2-amino-3-phenylpropanol 

Downstream Products

• 173204-71-2 tert-butyl (S)-N-methyl-N-(1-oxo-3-phenylpropan-2-yl)carbamate 
• 732282-65-4 (S)-3-(N-tert-butoxycarbonyl-2-methylamino-3-phenylpropyl)-1-(2,6-difluorobenzyl)-5-(2-fluoro-3-methoxyphenyl)-6-methyluracil 
• 732282-64-3 (S)-5-bromo-3-(N-tert-butoxycarbonyl-2-methylamino-3-phenylpropyl)-1-(2,6-difluorobenzyl)-6-methyluracil 

Relevant articles and documents

Discovery of Arylsulfonamide Nav1.7 Inhibitors: IVIVC, MPO Methods, and Optimization of Selectivity Profile

The voltage-gated sodium channel Nav1.7 continues to be a high-profile target for the treatment of various pain afflictions due to its strong human genetic validation. While isoform selective molecules have been discovered and advanced into the clinic, to date, this target has yet to bear fruit in the form of marketed therapeutics for the treatment of pain. Lead optimization efforts over the past decade have focused on selectivity over Nav1.5 due to its link to cardiac side effects as well as the translation of preclinical efficacy to man. Inhibition of Nav1.6 was recently reported to yield potential respiratory side effects preclinically, and this finding necessitated a modified target selectivity profile. Herein, we report the continued optimization of a novel series of arylsulfonamide Nav1.7 inhibitors to afford improved selectivity over Nav1.6 while maintaining rodent oral bioavailability through the use of a novel multiparameter optimization (MPO) paradigm. We also report in vitro-in vivo correlations from Nav1.7 electrophysiology protocols to preclinical models of efficacy to assist in projecting clinical doses. These efforts produced inhibitors such as compound 19 with potency against Nav1.7, selectivity over Nav1.5 and Nav1.6, and efficacy in behavioral models of pain in rodents as well as inhibition of rhesus olfactory response indicative of target modulation.

COMPOUNDS FOR USE IN IMAGING, DIAGNOSING, AND/OR TREATMENT OF DISEASES OF THE CENTRAL NERVOUS SYSTEM OR OF TUMORS

This invention relates to novel compounds suitable for labelling or already labelled by 18F, methods of preparing such a compound, compositions comprising such compounds, kits comprising such compounds or compositions and uses of such compounds

A practical protocol for chemoselective N-methylation of vicinal amino alcohols

A practical method for the chemoselective N-methylation of vicinal amino alcohols is described. (C) 2000 Elsevier Science Ltd.