264130-02-1

Basic information

• Product Name: 11β-(2-methyl-2-phenyl-1,3-dioxalan)-17α-(3-methyl-1-butynyl)-estra-9-en-5α,17β-diol-3-one, cyclic 1,2-ethandiyl acetal
• Synonyms: 11β-(2-methyl-2-phenyl-1,3-dioxalan)-17α-(3-methyl-1-butynyl)-estra-9-en-5α,17β-diol-3-one, cyclic 1,2-ethandiyl acetal
• CAS NO: 264130-02-1
• Molecular Weight: 562.747
• Mol File: 264130-02-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 11β-(2-methyl-2-phenyl-1,3-dioxalan)-17α-(3-methyl-1-butynyl)-estra-9-en-5α,17β-diol-3-one, cyclic 1,2-ethandiyl acetal(CAS DataBase Reference)
• NIST Chemistry Reference: 11β-(2-methyl-2-phenyl-1,3-dioxalan)-17α-(3-methyl-1-butynyl)-estra-9-en-5α,17β-diol-3-one, cyclic 1,2-ethandiyl acetal(264130-02-1)
• EPA Substance Registry System: 11β-(2-methyl-2-phenyl-1,3-dioxalan)-17α-(3-methyl-1-butynyl)-estra-9-en-5α,17β-diol-3-one, cyclic 1,2-ethandiyl acetal(264130-02-1)

Safety Data

• Hazardous Substances Data: 264130-02-1(Hazardous Substances Data)

Upstream product

• 4360-68-3 2-(4-bromophenyl)-2-methyl-1,3-dioxolane 
• 264130-00-9 estra-5α,10α-epoxy-9(11)-en-3-one, 17β-hydroxy-17α-(3-methyl-1-butynyl) cyclic 3-(1,2-ethanediyl acetal) 
• 5571-36-8 ethylene deltenone 
• 264129-99-9 estra-5(10),9(11)-dien-3-one, 17β-hydroxy-17α-(3-methyl-1-butynyl) cyclic 3-(1,2-ethanediyl acetal) 

Relevant articles and documents

Synthesis of 11β-(4-dimethylaminophenyl)-17β-hydroxy-17α-(3-methyl-1-butynyl)-4,9-estra dien-3-one and 11β-(4-acetophenyl)-17β-hydroxy-17α-(3-methyl-1-butynyl)-4,9-estradien-3-one: Two new analogs of mifepristone (RU-486)

From the structure activity relationship, two new analogs, 2 and 3, of the potent progesterone antagonist mifepristone 1 have been designed. The syntheses of these two analogs have been achieved in eleven steps through modified synthetic sequences and improved procedures starting from (+)-estrone. In comparison with mifepristone 1, the relative binding affinities of compound 2 for the progesterone receptor was found to be more, whereas that of compound 3 was less. Copyright (C) 2000 Elsevier Science Inc.