264135-49-1

Basic information

• Product Name: 2,4-DIFLUOROPHENYL TRIFLUOROMETHANESULFONATE
• Synonyms: 2,4-DIFLUOROPHENYL TRIFLUOROMETHANESULFONATE;2,4-DIFLUOROPHENYL TRIFLUOROMETHANESULFONATE, 97% MIN.;2,4-Difluorophenyl trifluoromethanesulphonate 97%;2,4-Difluorophenyl triflate;2,4-Difluorophenyltrifluoromethanesulphonate97%
• CAS NO: 264135-49-1
• Molecular Formula: C7H3F5O3S
• Molecular Weight: 262.15
• Mol File: 264135-49-1.mol

Chemical Properties

• Boiling Point: 231.428°C at 760 mmHg
• Flash Point: 93.764°C
• Appearance: /
• Density: 1.646g/cm³
• Vapor Pressure: 0.095mmHg at 25°C
• Refractive Index: 1.447
• CAS DataBase Reference: 2,4-DIFLUOROPHENYL TRIFLUOROMETHANESULFONATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DIFLUOROPHENYL TRIFLUOROMETHANESULFONATE(264135-49-1)
• EPA Substance Registry System: 2,4-DIFLUOROPHENYL TRIFLUOROMETHANESULFONATE(264135-49-1)

Safety Data

• Hazardous Substances Data: 264135-49-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2,4-DIFLUOROPHENYL TRIFLUOROMETHANESULFONATE is used as a reagent for the synthesis of pharmaceuticals, as it facilitates the sulfonation of organic compounds, which is a key step in the production of various drugs.
Used in Agrochemical Industry:
2,4-DIFLUOROPHENYL TRIFLUOROMETHANESULFONATE is used as a reagent in the synthesis of agrochemicals, where its strong electrophilic trifluoromethanesulfonylating properties enable the creation of new compounds with potential pesticidal or herbicidal activity.
Used in Organic Chemistry Research:
2,4-DIFLUOROPHENYL TRIFLUOROMETHANESULFONATE is used as a reagent for the modification of functional groups in organic molecules, allowing for the exploration of new chemical reactions and the development of novel organic compounds.
Used in Fluorine Chemistry:
2,4-DIFLUOROPHENYL TRIFLUOROMETHANESULFONATE is used as a precursor in the preparation of various organic fluorine compounds, which are valuable due to their unique properties and applications in various fields, such as materials science and medicinal chemistry.

InChI:InChI=1/C7H3F5O3S/c8-4-1-2-6(5(9)3-4)15-16(13,14)7(10,11)12/h1-3H

Upstream product

• 358-23-6 trifluoromethylsulfonic anhydride 
• 367-27-1 2,4-difluorophenol 

Relevant articles and documents

Air-Stable PdI Dimer Enabled Remote Functionalization: Access to Fluorinated 1,1-Diaryl Alkanes with Unprecedented Speed

While remote functionalization via chain walking has the potential to enable access to molecules via novel disconnections, such processes require relatively long reaction times and can be in need of elevated temperatures. This work features a remote arylation in less than 10 min reaction time at room temperature over a distance of up to 11 carbons. The unprecedented speed is enabled by the air-stable PdI dimer [Pd(μ-I)(PCy2tBu)]2, which in contrast to its PtBu3 counterpart does not trigger direct coupling at the initiation site, but regioconvergent and chemoselective remote functionalization to yield valuable fluorinated 1,1-diaryl alkanes. Our combined experimental and computational studies rationalize the origins of switchability, which are primarily due to differences in dispersion interactions.

Coupling reactions of alkynylsilanes mediated by a Cu(I) salt: Novel syntheses of conjugate diynes and disubstituted ethynes

Reaction of 1-trimethylsilylalkyne with copper(I) chloride in a polar solvent, DMF, at 60 °C under an aerobic conditions smoothly undergoes homo- coupling to give the corresponding symmetrical 1,3-butadiynes in 70-99% yields. In addition, (arylethynyl)trimethylsilanes are found to couple with aryl triflates and chlorides in the presence of Cu(I)/Pd(0) (10 mol %/5 or 10 mol %) cocatalyst system to give the corresponding diarylethynes in 49-99% yields. The cross-coupling reaction is applied to a one-pot synthesis of the corresponding unsymmetrical diarylethynes from (trimethylsilyl)ethyne via sequential Sonogashira-Hagihara and the present cross-coupling reactions using two different aryl triflates. The reactions of (arylethynyl)trimethylsilanes with aryl(chloro)ethynes in the presence of 10 mol % of CuCl also yield the corresponding unsymmetrical 1,3-butadiynes in 43-97% yields.