26419-17-0

Upstream product

• 104-94-9 4-methoxy-aniline 
• 122-51-0 orthoformic acid triethyl ester 

Downstream Products

• 5961-59-1 N-methyl-N-(4-methoxyphenyl)amine 
• 106575-62-6 2-[(2S,3S)-1-(4-Methoxy-phenyl)-2-(2-methyl-[1,3]dioxolan-2-ylmethoxy)-4-oxo-azetidin-3-yl]-isoindole-1,3-dione 
• 106575-63-7 2-[(3S,4S)-1-(4-Methoxy-phenyl)-2-oxo-4-(2-oxo-propoxy)-azetidin-3-yl]-isoindole-1,3-dione 
• 106575-61-5 (3R,4R)-1-(4-Methoxy-phenyl)-4-(2-methyl-[1,3]dioxolan-2-ylmethoxy)-3-phenoxy-azetidin-2-one 
• 106575-64-8 (3R,4R)-1-(4-Methoxy-phenyl)-4-(2-oxo-propoxy)-3-phenoxy-azetidin-2-one 
• 97968-72-4 1,5-Dihydro-5-(4-methoxyphenyl)-4H-pyrazolo<3,4-d>pyrimidin-4-one 
• 106575-60-4 2,2-Ethanediyldioxypropyl N-(4-methoxyphenyl)-formamidate 

Relevant academic research and scientific papers

Multicomponent synthesis of 1-aryl 1,2,4-triazoles

A multicomponent (single reactor) process for the synthesis of 1-aryl 1,2,4-triazoles was explored and developed. This transformation prepared the 1,2,4-triazole directly from anilines, amino pyridines, and pyrimidines. The reaction scope was explored with 21 different substrates, and the position of the nitrogen atoms in the newly formed ring was established by 15N labeling and NMR spectroscopy.

A facile protocol for the synthesis of mono-N-methyl anilines via formimidate intermediates

A general procedure for the preparation of mono-N-methyl anilines has been developed with excellent yields. This protocol relies on a NaBH3(OAc) reduction of formimidate intermediates that are quantitatively generated by treatment of primary substituted anilines with triethyl orthoformate under the catalysis of MCM-41-SO3H mesoporous zeolite. The newly developed procedure was facile, efficient, and environmentally benign.