264204-73-1Relevant articles and documents
Synthesis and structure-activity relationships of a new class of selective EP3 receptor agonist, 13,14-didehydro-16-phenoxy analogues of prostaglandin E1
Shimazaki, Youichi,Kameo, Kazuya,Tanami, Tohru,Tanaka, Hideo,Ono, Naoya,Kiuchi, Youichi,Okamoto, Sentaro,Sato, Fumie,Ichikawa, Atsushi
, p. 353 - 362 (2007/10/03)
A series of 13,14-didehydro-16-phenoxy analogues of prostaglandin E1 was synthesized and their agonistic activity on EP receptor subtypes was evaluated. 13,14-Didehydro-16-phenoxy-1-decarboxy analogues, 7e and 7f, display highly selective activity on the EP3 receptor subtype, thus, their utility as a selective anti-ulcer agent can be expected. (C) 2000 Elsevier Science Ltd.