264208-45-9

Basic information

• Product Name: 5-(4-FLUORO-PHENYL)-2,4-DIHYDRO-PYRAZOL-3-ONE
• Synonyms: 5-(4-FLUORO-PHENYL)-2,4-DIHYDRO-PYRAZOL-3-ONE;AKOS USSH-0098;BUTTPARK 41\07-26;2,4-DIHYDRO-5-(4-FLUOROPHENYL)-3H-PYRAZOL-3-ONE;3-(4-Fluorophenyl)-1H-pyrazol-5(4H)-one;5-(4-fluorophenyl)-2,4-dihydro-3H-Pyrazol-3-one
• CAS NO: 264208-45-9
• Molecular Formula: C₉H₇FN₂O
• Molecular Weight: 178.16
• Mol File: 264208-45-9.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.37 g/cm³
• PKA: 12.53±0.40(Predicted)
• CAS DataBase Reference: 5-(4-FLUORO-PHENYL)-2,4-DIHYDRO-PYRAZOL-3-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(4-FLUORO-PHENYL)-2,4-DIHYDRO-PYRAZOL-3-ONE(264208-45-9)
• EPA Substance Registry System: 5-(4-FLUORO-PHENYL)-2,4-DIHYDRO-PYRAZOL-3-ONE(264208-45-9)

Safety Data

• Hazardous Substances Data: 264208-45-9(Hazardous Substances Data)

Usage

General Description

The chemical 5-(4-Fluoro-phenyl)-2,4-dihydro-pyrazol-3-one is an organic compound with a molecular formula C10H9FN2O. It is a pyrazolone derivative with a 4-fluorophenyl group attached to the 5th carbon, and a dihydro-2,4-pyrazolone ring. 5-(4-Fluoro-phenyl)-2,4-dihydro-pyrazol-3-one has potential pharmaceutical applications, particularly in the development of new drugs for various therapeutic uses. It is important to handle and use this chemical with care, following all necessary safety precautions and guidelines to prevent any potential hazards.

Upstream product

• 63131-29-3 methyl 4-fluorobenzoyl acetate 

Relevant articles and documents

QUINAZOLINE DERIVATIVES

The invention relates to the use of compounds of the formula I: wherein: ring C is a 5-6 membered heterocyclic moiety; Z is -O-, -S-, or -CH2-; R1 is hydrogen, C1-4alkyl, C1-4alkoxymethyl, di(C1-4)alkoxy)methyl, C1-4alkanoyl, trifluoromethyl, cyano, amino, C2-5alkenyl, C2-5alkynyl, carboxy, C3-7cycloalkyl, C3-7-cycloalkylC1-3alkyl, or an optionally substituted group selected from phenyl, benzyl, phenylC2-4alkyl and a 5-6 membered heterocyclic group; n is an integer from 0 to 5; m is an integer from 0 to 3; R2 represents hydrogen, hydroxy, halgeno, cyano, nitro, trifluoromethyl, C1-3alkyl, C1-3alkoxy, C1-3alkylsulphanyl, -NR3R4 (wherein R3 and R4, which may be the same or different, each represents hydrogen or C1-3alkyl), or R5X1- (wherein X1 represents a direct bond, -CH2-, or a heteroatom linker group and R5 is an alkyl, alkenyl or alkynyl chain optionally substituted by for example hydroxy, amino, nitro, alkyl, cycloalkyl, alkoxyalkyl, or an optionally substituted group selected from pyridone, phenyl and a heterocyclic ring, which alkyl, alkenyl or alkynyl chain may have a heteroatom linker group, or R5 is an optionally substituted group selected from pyridone, phenyl and a heterocyclic ring, and salts thereof, in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in warm-blooded animals, processes for the preparation of such compounds, pharmaceutical compositions containing a compound of formula I or a pharmaceutically acceptable salt thereof as active ingredient and compounds of formula I. The compounds of formula I and the pharmaceutically acceptable salts thereof inhibit the effects of VEGF, a property of value in the treatment of a number of disease states including cancer and rheumatoid arthritis.