264224-82-0

Basic information

• Product Name: (E)-4-methyl-2-(2-nitrovinyl)phenol
• Synonyms: (E)-4-methyl-2-(2-nitrovinyl)phenol
• CAS NO: 264224-82-0
• Molecular Weight: 179.175
• Mol File: 264224-82-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (E)-4-methyl-2-(2-nitrovinyl)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-4-methyl-2-(2-nitrovinyl)phenol(264224-82-0)
• EPA Substance Registry System: (E)-4-methyl-2-(2-nitrovinyl)phenol(264224-82-0)

Safety Data

• Hazardous Substances Data: 264224-82-0(Hazardous Substances Data)

Upstream product

• 75-52-5 nitromethane 
• 613-84-3 2-hydroxy-5-methylbenzaldehyde 

Downstream Products

• 1392824-47-3 (S)-ethyl 1-[(R)-1-(2-hydroxy-5-methylphenyl)-2-nitroethyl]-2-oxocyclopentanecarboxylate 
• 1392824-48-4 (3aS,9R,9aS)-ethyl 3a-hydroxy-7-methyl-9-(nitromethyl)-1,2,3,3a,9,9a-hexahydrocyclopenta[b]chromene-9acarboxylate 
• 1384976-24-2 1-(4-methyl-2-((E)-2-nitrovinyl)phenoxy)propan-2-one 

Relevant articles and documents

Organocatalytic Enantioselective Michael-Acetalization-Henry Reaction Cascade of 2-Hydroxynitrostyrene and 5-Oxohexanal for the Entry to the Hexahydro-6H-benzo[c]chromenones with Four Consecutive Stereogenic Centers and an Approach to Aflatoxin Analogues

A domino reaction with the organocatalytic enantioselective Michael-acetalization-Henry reaction of 2-hydroxynitrostyrene and 5-oxohexanal was developed for the synthesis of hexahydro-6H-benzo[c]chromenones with four consecutive stereogenic centers and high enantioselectivity (up to >99% ee). The transformation of a NaBH4-reduced adduct to the aflatoxin system via the Nef-cyclization process was achieved by the assistant of ZnBr2.