264229-65-4Relevant academic research and scientific papers
Stereoselective alkylation-reduction of β-keto nitriles by the fungus Curvularia lunata
Dehli, Juan R.,Gotor, Vicente
, p. 1485 - 1492 (2007/10/03)
The alkylation-reduction (AR) reaction of β-keto nitriles by growing cells of Curvularia lunata CECT 2130 has been explored. The reaction conditions for the ethylation of benzoylacetonitrile have been optimized in terms of both yield and stereoselectivity and the mechanism of this biotransformation was studied. The scope of this reaction has been extended to other alkylations (R = Et, Pr, Bu, iso-Bu) and to a series of aromatic and heteroaromatic substrates, yielding the corresponding optically active α-alkyl β-hydroxy nitriles. The yield (directly related to competing carbonyl reduction reaction) depends on the substrate bulk, whereas the enantiomeric and diastereomeric excesses (both up to 98%) seem to be dependent on several factors.
Biotransformations of benzoylacetonitrile with the fungus Curvularia lunata: Highly diastereo- and enantioselective synthesis of α-alkyl β-hydroxy nitriles and γ-amino alcohols
Gotor, Vicente,Dehli, Juan R.,Rebolledo, Francisca
, p. 307 - 309 (2007/10/03)
Incubation of alcoholic solutions of benzoylacetonitrile, 1, with a suitable aqueous culture of C. lunata results in highly diastereo- and enantioselective reactions leading to α-alkyl β-hydroxy nitriles 3, which are easily reduced to the corresponding γ-
