264253-91-0Relevant academic research and scientific papers
New quinolinic derivatives as centrally active antioxidants
Dorey, Gilbert,Lockhart, Brian,Lestage, Pierre,Casara, Patrick
, p. 935 - 939 (2000)
A series of new 1,2-dihydro and 1,2,3,4-tetrahydroquinolines, synthesized from the corresponding propargylaniline intermediates, have been developed as antioxidants for the potential treatment of pathologies implicating central oxidative stress. (C) 2000 Elsevier Science Ltd. All rights reserved.
Dihydro- and tetrahydro-quinoline compounds
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, (2008/06/13)
Compound of formula (I): wherein: R1represents hydrogen or wherein A is as defined in the description, R2and R3each independently represents alkyl, cycloalkyl, heterocycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, cycloalkylalkyl, heterocycloalkylalkyl, optionally substituted arylalkyl, optionally substituted heteroarylalkyl,or optionally substituted aminoalkyl or R2and R3, together with the carbon atom carrying them, form cycloalkyl or monocyclic heterocyclic group, substituted or unsubstituted, R40represents hydrogen or a group selected from optionally substituted alkyl, optionally substituted alkenyl and optionally substituted alkynyl or Q or —V—Q wherein V represents alkylene, alkenylene or alkynylene and Q represents optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heterocycloalkyl,or optionally substituted heteroaryl, R41and R5together form a bond or each represents hydrogen, R6, R7, R8and R9each independently represents hydrogen, halogen, alkyl, (C3-C8)cycloalkyl,or —OW wherein W is as defined in the description, and medicinal products containing the same which are useful as antioxidative agents.
