2644-25-9

Basic information

• Product Name: N,N-Diisobutylglycine ethyl ester
• Synonyms: N,N-Diisobutylglycine ethyl ester
• CAS NO: 2644-25-9
• Molecular Formula: C12H25 N O2
• Molecular Weight: 215.33
• Mol File: 2644-25-9.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 258.3°Cat760mmHg
• Flash Point: 77°C
• Appearance: /
• Density: 0.904g/cm³
• Vapor Pressure: 0.0138mmHg at 25°C
• Refractive Index: 1.442
• PKA: 7.22±0.50(Predicted)
• CAS DataBase Reference: N,N-Diisobutylglycine ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-Diisobutylglycine ethyl ester(2644-25-9)
• EPA Substance Registry System: N,N-Diisobutylglycine ethyl ester(2644-25-9)

Safety Data

• Hazardous Substances Data: 2644-25-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H25NO2/c1-6-15-12(14)9-13(7-10(2)3)8-11(4)5/h10-11H,6-9H2,1-5H3

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 110-96-3 diisobutylamine 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 2644-37-3 N,N-diisobutyl-glycine hydrazide 

Relevant articles and documents

Carbene Transfer and Carbene Insertion Reactions Catalyzed by a Mixed-Ligand Copper(I) Complex

The catalytic activity of the mixed-ligand copper(I) complex [Cu(PPh3)2(κ2-O,O"-lact)] (1) {lact = l-(+)-lactate} has been investigated in carbene transfer and carbene insertion reactions. Complex 1 catalytically promoted the diastereoselective cyclopropanation of olefins in the presence of ethyl diazoacetate (EDA), under mild conditions, and with a low catalyst loading (1 mol-%). In the case of internal alkenes, a trans/cis ratio of up to 93:7 was reached. Moreover, compound 1 easily promoted the insertion of the carbene fragment deriving from the decomposition of ethyl diazoacetate into O–H (alcohols and phenols) and N–H (amine) bonds, with formation of the corresponding ethyl 2-alkoxyacetate, ethyl 2-phenoxyacetate, and ethyl 2-aminoacetate derivatives in good to high yields.