26458-04-8

Basic information

• Product Name: 1-TRIFLUOROMETHYL-NAPHTHALENE
• Synonyms: 1-TRIFLUOROMETHYL-NAPHTHALENE;(trifluoromethyl)naphthalene;1-(Trifluoromethyl)naphthalene 95%
• CAS NO: 26458-04-8
• Molecular Formula: C₁₁H₇F₃
• Molecular Weight: 196.17
• Mol File: 26458-04-8.mol

Chemical Properties

• Boiling Point: 73-75 °C(Press: 3 Torr)
• Flash Point: 93℃
• Appearance: /
• Density: 1.263 g/mL at 25 °C
• Refractive Index: n20/D1.537
• CAS DataBase Reference: 1-TRIFLUOROMETHYL-NAPHTHALENE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-TRIFLUOROMETHYL-NAPHTHALENE(26458-04-8)
• EPA Substance Registry System: 1-TRIFLUOROMETHYL-NAPHTHALENE(26458-04-8)

Safety Data

• Hazard Codes: Xn,N
• Statements: 36/37/38-51/53-22
• Safety Statements: 26-36/37/39-61
• RIDADR: UN 3082 9 / PGIII
• WGK Germany: 3
• Hazardous Substances Data: 26458-04-8(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 32, p. 7689, 1991 DOI: 10.1016/0040-4039(91)80566-O

Upstream product

• 680-15-9 2,2-difluoro-2-(fluorosulfonyl)acetate 
• 90-11-9 1-Bromonaphthalene 
• 90-14-2 1-Iodonaphthalene 
• 2314-97-8 iodotrifluoromethane 
• 13922-41-3 1-Naphthylboronic acid 
• 68716-52-9 1-naphthylboronic acid pinacol ester 

Downstream Products

• 306-92-3 perfluoro 1-methyldecaline 
• 112298-32-5 1-(trifluoromethyl)-1,2,3,4-tetrahydronaphthalene 
• 24913-62-0 3-trifluoromethylphthalic acid 
• 90-12-0 1-Methylnaphthalene 

Relevant articles and documents

Oxidative trifluoromethylation of arylboronates with shelf-stable potassium (trifluoromethyl)trimethoxyborate

Introducing CF3: Arylboronic acid pinacol esters are converted into the corresponding benzotrifluorides with the easy-to-use one-component trifluoromethylating reagent potassium (trifluoromethyl)trimethoxyborate, mediated by copper acetate under an oxygen atmosphere (see scheme). Copyright

Merging visible-light photocatalysis and transition-metal catalysis in the copper-catalyzed trifluoromethylation of boronic acids with CF3I

This communication describes the development of a mild method for the cross-coupling of arylboronic acids with CF3I via the merger of photoredox and Cu catalysis. This method has been applied to the trifluoromethylation of electronically diverse aromatic and heteroaromatic substrates and tolerates many common functional groups.

Copper electron-transfer induced trifluoromethylation with methyl fluorosulphonyldifluoroacetate

Treatment of halogen compounds, RX, with methyl fluorosulfonyldifluoroacetate and copper powder in dimethylformamide for 4 h at 65 - 80 deg C resulted in the corresponding trifluoromethylated products, RCF3, in good yield.In the absence of halogen compounds and at 100 deg C, methyl triflone (CF3SO2CH3) was synthesized readily in the 20 - 30percent yield from the same reaction system.The fact that the reaction was suppressed by oxygen, p-dinitrobenzene or in the darkness suggested that a copper-induced electron-transfer process was involved in this new trifluoromethylating system.

Methyl Fluorosulphonyldifluoroacetate; a New Trifluoromethylating Agent

Methyl fluorosulphonyldifluoroacetate, in the presence of copper(I) iodide, is used as the source of trifluoromethyl group which replaces the halogen in aryl, alkenyl, and alkyl halides.