2646-38-0

Basic information

• Product Name: CHENODEOXYCHOLIC ACID SODIUM
• Synonyms: 3-alpha,7-alpha-dihydroxy-5-beta-cholan-24-oicacimonosodiumsalt;cholan-24-oicacid,3,7-dihydroxy-,monosodiumsalt,(3-alpha,5-beta,7-alpha);sodiumchenodeoxycholate;sodiumchenodesoxycholate;CHENODEOXYCHOLIC ACID SODIUM;3α,7α-Dihydroxy-5β-cholanic acid, 5β-Cholanic acid-3α,7α-diol, Chenodeoxycholic acid sodium salt, Chenodesoxycholic acid, Chenodiol;3α,7α-Dihydroxy-5β-cholan-24-oic acid sodium salt;Chenodiol Chenodesoxycholic acid
• CAS NO: 2646-38-0
• Molecular Formula: C₂₄H₃₉O₄*Na
• Molecular Weight: 414.55383
• Mol File: 2646-38-0.mol

Chemical Properties

• Melting Point: 298 °C(dec.)
• Boiling Point: 547.1°Cat760mmHg
• Flash Point: 298.8°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 2.98E-14mmHg at 25°C
• Storage Temp.: +15C to +30C
• CAS DataBase Reference: CHENODEOXYCHOLIC ACID SODIUM(CAS DataBase Reference)
• NIST Chemistry Reference: CHENODEOXYCHOLIC ACID SODIUM(2646-38-0)
• EPA Substance Registry System: CHENODEOXYCHOLIC ACID SODIUM(2646-38-0)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-40
• Safety Statements: 22-36
• WGK Germany: 3
• RTECS: FZ2231000
• Hazardous Substances Data: 2646-38-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
CHENODEOXYCHOLIC ACID SODIUM is used as a pharmaceutical compound for its ability to aid in the absorption and emulsification of dietary fats. It is particularly useful in the treatment of certain digestive disorders and conditions related to fat metabolism.
Used in Research and Development:
CHENODEOXYCHOLIC ACID SODIUM is used as a research compound for studying the interaction between dietary bioactive peptides of short length and bile salts in submicellar or micellar state. This helps in understanding the role of bile acids in fat digestion and absorption, as well as their potential therapeutic applications.
Used in Rat Hepatocyte Studies:
In the field of cellular and molecular biology, CHENODEOXYCHOLIC ACID SODIUM is used as a bile acid in rat hepatocyte studies. These studies are essential for understanding the role of bile acids in liver function and their potential impact on various metabolic processes.

InChI:InChI=1/C24H40O4.Na/c1-14(4-7-21(27)28)17-5-6-18-22-19(9-11-24(17,18)3)23(2)10-8-16(25)12-15(23)13-20(22)26;/h14-20,22,25-26H,4-13H2,1-3H3,(H,27,28);/t14-,15+,16-,17-,18+,19+,20+,22+,23+,24-;/m1./s1

Upstream product

• 1310-73-2 sodium hydroxide 
• 128-13-2 ursodeoxycholic acid 
• 474-25-9 chenodeoxycholic acid 

Downstream Products

• 78919-26-3 3β,7β-dihydroxy-5β-cholan-24-oic acid 
• 77060-26-5 3-keto-7β-hydroxy-5β-cholan-24-oic acid 
• 566-24-5 3β,7α-dihydroxy-5β-cholan-24-oic acid 
• 474-25-9 chenodeoxycholic acid 
• 4651-67-6 7-Ketolithocholic acid 
• 859-97-2 3,7-diketocholanic acid 
• 80202-72-8 3,7ξ-dihydroxy-9,10-seco-1,3,5(10)-androstatriene-9,17-dione 
• 4185-00-6 Dehydrochenodeoxycholic acid 

Relevant articles and documents

Synthesis, characterization and biological activity of hydroxyl- bisphosphonic analogs of bile acids

Bisphosphonates (BPs) are now the most widely used drugs for diseases associated with increased bone resorption, such as osteoporosis, and tumor bone diseases. A significant drawback of the BPs is their poor oral absorption that is enhanced by the presence of bile acid substituents in the bisphosphonate framework, with no toxic effects. A straightforward synthesis of bile acid-containing hydroxy-bisphosphonates and a full characterization of these pharmaceutically important molecules, including an evaluation of affinity and the mechanism of binding to hydroxyapatite, is presented. The biological activity of bile acid-containing bisphosphonate salts was determined using the neutral-red assay on the L929 cell line and primary cultures of osteoclasts. The bioactivity of the new compounds was found superior than bisphosphonates of established activity.

Dansyl-labeled cholic acid as a tool to build speciation diagrams for the aggregation of bile acids

Bile acids (BAs) are a family of natural steroids biosynthesized from cholesterol in the liver that tend to form aggregates in solution. A fluorescent derivative of cholic acid, namely 3α-Dns-ChA, was employed as a reporter to establish the speciation diagrams of the most abundant BAs that can be found mainly in three microenvironments, solution, and primary and secondary aggregates. The developed methodology is based on the analysis of the combined steady-state and time-resolved experiments performed on 3α-Dns-ChA whose emission behavior was found to be strongly medium dependent. In particular, speciation diagrams of sodium glycocholate (NaGCh), sodium taurocholate (NaTCh), sodium chenodeoxycholate (NaCDCh), sodium glycochenodeoxycholate (NaGCDCh), sodium deoxycholate (NaDCh), and sodium ursodeoxycholate (NaUDCh) were successfully built up.

A process for the preparation of cholanic acids

A process for the preparation of high purity cholanic acids, typically in purity equal to or higher than 99%.