2646-71-1 Usage
Uses
Used in General Biochemical Applications:
BETA-NADPH TETRASODIUM SALT is used as a coenzyme and biological reducing agent for various redox reactions, carrying electrons from one reaction to another, and serving as a cofactor for many redox enzymes, including nitric oxide synthetase.
Used in Antioxidation Mechanisms:
BETA-NADPH TETRASODIUM SALT is used as an electron donor in a variety of antioxidation mechanisms, where it protects against reactive oxidation species accumulation.
Used in Biosynthetic Reactions:
BETA-NADPH TETRASODIUM SALT is used as a reducing agent in anabolic reactions such as lipid and cholesterol biosynthesis, as well as fatty acyl chain elongation.
Used in Photosynthesis:
In plants, BETA-NADPH TETRASODIUM SALT is used as an electron donor in the formation of carbohydrates from CO2 during photosynthesis.
Used in Erythrocytes:
BETA-NADPH TETRASODIUM SALT is used to maintain high levels of reduced glutathione in erythrocytes, playing a role in the reduction of thioredoxin.
Used in the Pentose Phosphate Pathway:
BETA-NADPH TETRASODIUM SALT is generated in vivo by the pentose phosphate pathway, which is predominantly responsible for its production in animals.
Chemical Properties:
BETA-NADPH TETRASODIUM SALT is an off-white to light yellow powder.
Biological Activity
NADPH is an electron donor and a cofactor for many redox enzymes including nitric oxide synthetase.β-Nicotinamide adenine dinucleotide 2′-phosphate (NADP+) and β-Nicotinamide adenine dinucleotide 2′-phosphate, reduced (NADPH) comprise a coenzyme redox pair (NADP+:NADPH) involved in a wide range of enzyme catalyzed oxidation reduction reactions. The NADP+/NADPH redox pair facilitates electron transfer in anabolic reactions such as lipid and cholesterol biosynthesis and fatty acyl chain elongation. The NADP+/NADPH redox pair is used in a variety of antioxidation mechanism where it protects agains reactive oxidation species accumulation. NADPH is generated in vivio by the pentose phosphate pathway (PPP).
Biochem/physiol Actions
NADPH is an electron donor and a cofactor for many redox enzymes including nitric oxide synthetase.
Purification Methods
Purification is mostly similar to that of NADH above. [Beilstein 26 III/IV 3671.]
Check Digit Verification of cas no
The CAS Registry Mumber 2646-71-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,6,4 and 6 respectively; the second part has 2 digits, 7 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 2646-71:
(6*2)+(5*6)+(4*4)+(3*6)+(2*7)+(1*1)=91
91 % 10 = 1
So 2646-71-1 is a valid CAS Registry Number.
InChI:InChI=1/C21H30N7O17P3.4Na/c22-17-12-19(25-7-24-17)28(8-26-12)21-16(44-46(33,34)35)14(30)11(43-21)6-41-48(38,39)45-47(36,37)40-5-10-13(29)15(31)20(42-10)27-3-1-2-9(4-27)18(23)32;;;;/h1,3-4,7-8,10-11,13-16,20-21,29-31H,2,5-6H2,(H2,23,32)(H,36,37)(H,38,39)(H2,22,24,25)(H2,33,34,35);;;;/q;4*+1/p-4/t10-,11-,13+,14-,15+,16+,20+,21-;;;;/m1..../s1
