26471-62-5 Usage
Description
Toluene diisocyanate (TDI) is an aromatic diisocyanate that
is a clear, pale yellow liquid with a sharp, pungent odor,
which is insoluble in water and miscible with most common
organic solvents. TDI (CAS No. 26471-62-5) consists of two
isomers: toluene-2,4-diisocyanate (2,4-TDI) (CAS No. 584-
84-9) and toluene-2,6-diisocyanate (2,6-TDI) (CAS No. 91-
08-7), which is commercially produced in different ratios.
The most common ratio is 80% 2,4-TDI/20% 2,6 TDI. TDI is
widely used and accounted for 34% of the global isocyanate
market in 2000.
Chemical Properties
Toluene diisocyanate is a colorless, yellow, or dark liquid or solid. It has a sweet, fruity, pungent odor. Toluene diisocyanate (technical, 26471-62-5) is an 80: 20 mixture of 2,4-and 2,6-isomers. A solid above 71/F/22℃. The Odor Threshold is 0.4-2.14 ppm.
Uses
Different sources of media describe the Uses of 26471-62-5 differently. You can refer to the following data:
1. Toluene diisocyanates are used primarily to manufacture flexible polyurethane foams for use in furniture, bedding, and automotive and airline seats. Other, smaller uses are for polyurethane elastomers (for automobile bumper covers, industrial rollers, sport soles and boots, and mechanical goods) and coatings (for automotive refinishing, wood finishes, and high-performance anti-corrosion coatings)(ICIS 2009). Toluene diisocyanate–based rigid polyurethane foam is used in household refrigerators and for residential sheathing or commercial roofing in board or laminate form (IARC 1986). “Pour-inplace” or “spray-in” rigid foam is used as insulation for truck trailers, railroad freight cars, and cargo containers. Polyurethane-modified alkyds contain approximately 6% to 7% isocyanate, mostly toluene diisocyanates, and are used as coating materials, such as floor finishes, wood finishes, and paints. Moisture-curing coatings are used as wood and concrete sealants and floor finishes. Aircraft, truck, and passenger-car coatings often are composed of toluene diisocyanate prepolymer systems. Castable urethane elastomers are used in applications requiring strength, flexibility, and shock absorption, and are resistant to oil, solvents, and ultraviolet radiation. They are used in adhesive and sealant compounds and in automobile parts, shoe soles,rollerskate wheels, pond liners, and blood bags. They are also used inoil fields and mines. Certain elastomer products are produced from the pure 2,4 isomer rather than the 80:20 mixture.
2. The functional groups in TDI react with hydroxyl groups to
form urethane linkages, which are used in the manufacture of
flexible polyurethane foams for use in furniture, bedding, and
automotive and commercial transportation seating. Other uses
include polyurethane elastomers used in automobile bumper
covers, industrial rollers, sporting footwear, as well as
mechanical goods and coatings (metal, wood, and highperformance
anticorrosion coatings). TDI-based rigid polyurethane
foam is used in household refrigerators and for
residential construction such as sheathing and commercial
roofing. TDI spray-in rigid foam is used as insulation for truck
trailers, railroad freight cars, and overseas cargo containers.
Moisture-curing TDI coatings are used as wood and concrete
sealants and floor finishes.
General Description
A clear colorless to pale yellow liquid with a pungent odor. Denser than water. Burns, but may be difficult to ignite. Vapors are heavier than air. Vapors irritate the respiratory system. Toxic under prolonged exposure to vapor in low concentrations or short exposure to high concentrations of vapor. Carcinogenic. Produces toxic oxides of nitrogen during combustion. Used to make polyurethane foams and paints.
Air & Water Reactions
Reaction with water liberates carbon dioxide.
Reactivity Profile
TOLUENE DIISOCYANATE is explosive in the form of vapor-air mixture when exposed to heat, flame or sparks. Potentially violent polymerization reaction with strong bases or acyl chlorides. Reaction with aniline may generate enough heat to ignite unreacted portion and surrounding materials. Reaction with water liberates carbon dioxide. Potential explosion if stored in polyethylene containers due to absorption of water through the plastic. Emits toxic fumes of oxides of nitrogen when heated to decomposition[Lewis, 3rd ed., 1993, p. 1251].
Fire Hazard
TOLUENE DIISOCYANATE is combustible.
Flammability and Explosibility
Nonflammable
Contact allergens
Toluene diisocyanate is a mixture of 2,4-TDI and 2,6-
TDI. It is used in the manufacture of various polyurethane
products: elastic and rigid foams, paints, lacquers,
adhesives, binding agents, synthetics rubbers, and
elastomeric fibers.
Safety Profile
Confirmed carcinogen
with experimental carcinogenic and
neoplastigenic data. Poison by inhalation.
Moderately toxic by ingestion. Severe skin
irritant. Human mutation data reported.
Capable of producing severe dermatitis and
bronchal spasm. A common air
contaminant. A flammable liquid when
exposed to heat or flame. Explosive in the
form of vapor when exposed to heat or
flame. To fight fire, use dry chemical, COa.
Potentially violent polymerization reaction
with bases or acyl chlorides. Reaction with
water releases carbon dioxide. Storage in
polyethylene containers is hazardous due to
absorption of water through the plastic.
When heated to decomposition it emits
highly toxic fumes of NOx. See also
IS0CYANATES .
Potential Exposure
Toluene diisocyanate is used in the production of polyurethane flexible foams, coatings, paints, and elastomers. It is more widely used than MDI (diphenylmethane diisocyanate). Polyurethanes are formed by the reaction of isocyanates with polyhydroxy compounds. Since the reaction proceeds rapidly at room temperature, the reactants must be mixed in pots or spray guns just before use. These resins can be produced with various physical properties, for example, hard, flexible, semirigid foams; and have found many uses, for example, upholstery padding; thermal insulation; molds, surface coatings; shoe inner soles; and in rubbers, adhesives, paints, and textile finishes. Because of TDI’s high volatility, exposure can occur in all phases of its manufacture and use. MDI has a much lower volatility, and problems generally arise only in spray applications.
Carcinogenicity
Toluene diisocyanates are reasonably anticipated to be human carcinogens based on sufficient evidence of carcinogenicity from studies in experimental animals.
Environmental Fate
TDI is a synthetic organic chemical. It is a natural derivative
of primary amines with the general formula R–N]C]O
which does not occur naturally in the environment. At room
temperature, it can be a liquid or crystal. It is miscible with
alcohol, diglycol, monoethyl ether, ether, acetone, carbon
tetrachloride, benzene, chlorobenzene, kerosene, and olive
oil; however, it may react violently with alcohol, water, acid,
bases, and strong alkaline materials and tertiary amines and
generate enough heat to self-ignite and release toxic
combustion products. TDI reacts with water and most acids
producing unstable carbonic acids, which subsequently
decarboxylate yielding relatively chemically inert and
insoluble polymeric urea. Studies indicate that hydrolysis is
the dominant process in determining the overall environmental
fate, transport, and bioaccumulation potential
of TDI.
Although their rapid hydrolysis in surface water reduces
persistence and bioaccumulation in the environment, diisocyanates
may be stable long enough to be transported some
distances through the atmosphere and inhaled. Since the
hydrolysis products formed are irritants, there is a potential for
inhalation exposure. The degree stability is a function of
humidity. It is expected that TDI does not bioaccumulate
because the tendency to hydrolyze rapidly makes uptake and accumulation very unlikely. The bioconcentration factor ranges
from 151 to 1183 and the bioaccumulation factor is 380. These
values indicate that TDI has a low potential for bioaccumulation
in aquatic organisms. TDI is expected to hydrolyze
rapidly into its transformation products, making TDI
generally unavailable to aquatic organisms. The highly reactive
properties of diisocyanates are likely to be metabolized/
degraded at rates significant enough to counter any potential
for bioaccumulation or biomagnification. It is anticipated that
TDI released to water will primarily form inert polyureas,
which have the potential to be deposited to sediment, forming
an inert component of the sediment strata. While these polyureas
are persistent, studies have indicated that they pose
virtually no potential for adverse impacts on the aquatic
environment.
Shipping
UN2078 Toluene diisocyanate, Hazard Class: 6.1; Labels: 6.1-Poisonous materials.
Toxicity evaluation
TDI is a highly reactive compound. The toxicological properties
of isocyanates are attributed to the –N=C=O group. It is
thought to react vigorously and exothermically with water
forming an unstable carbamic acid that dissociates to form
a primary amine with liberation of CO2. Hence, the primary
amine will react further generating a urea derivative. TDI also
reacts readily with all organic compounds resulting in polymerization.
Such reactions denature proteins, form abnormal
cross-linkages, and generally disorganize the protein resulting
in alteration of its normal function. This reactivity with
proteins can account for its potency as a sensitizing agent. Thus,
more than one reaction may occur in a system at a given time.
The toxic effects of TDI can be attributed to two possible toxic
actions:
1. A primary irritant action on the mucous membranes of the
eyes, and the gastrointestinal and respiratory tracts, and
2. Bronchospasm due to either a pharmacological or an
immunological reaction.
This pharmacological reaction can be attributed to altered
β-adrenergic function or the blockade of the S-adrenergic
system by diminishing the formation of c-AMP after catecholamine
stimulation or perhaps to local histamine release. TDI
may also react with naturally occurring proteins or polysaccharides
to form immunohapten complexes.
Incompatibilities
May form explosive mixture with air. Isocyanates are highly flammable and reactive with many compounds, even with themselves. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Reaction with moist air, water or alcohols may form amines and insoluble polyureas and react exothermically, releasing toxic, corrosive or flammable gases, including carbon dioxide; and, at the same time, may generate a violent release of heat increasing the concentration of fumes in the air. Incompatible with amines, aldehydes, alkali metals, ammonia, carboxylic acids, caprolactum, alkaline materials, glycols, ketones, mercaptans, hydrides, organotin catalysts, phenols, strong acids, strong bases, strong reducing agents such as hydrides, urethanes, and ureas. Elevated temperatures or contact with acids, bases, tertiary amines, and acyl-chlorides may cause explosive polymerization. Attacks some plastics, rubber and coatings. Contact with metals may evolve flammable hydrogen gas. May accumulate static electrical charges, and may cause ignition of its vapors.
Waste Disposal
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Controlled incineration (oxides of nitrogen are removed from the effluent gas by scrubbers and/or thermal devices). In accordance with 40CFR165, follow recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office.
Check Digit Verification of cas no
The CAS Registry Mumber 26471-62-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,4,7 and 1 respectively; the second part has 2 digits, 6 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 26471-62:
(7*2)+(6*6)+(5*4)+(4*7)+(3*1)+(2*6)+(1*2)=115
115 % 10 = 5
So 26471-62-5 is a valid CAS Registry Number.
