26478-81-9Relevant academic research and scientific papers
Unexpected reactivity of pyridinium salts toward alkynyl Fischer complexes to produce oxo-heterocycles
Flores-Conde, María Inés,de la Cruz, Fabiola N.,López, Julio,Jiménez-Halla, J. óscar C.,Pe?a-Cabrera, Eduardo,Flores-álamo, Marcos,Delgado, Francisco,Vázquez, Miguel A.
, (2017/12/28)
The unprecedented reaction of ketone-containing aromatic pyridinium salts 3a-e and alkynyl Fischer complexes 1a-f proceeds via a mild domino process to provide 4,6-disubstituted pyran-2-ones 5a-k and 2,3,5-trisubstituted furans 6a-h (45-97%). According of the results of isotopic labeling experiments, a mechanism involving an initial Michael addition appears to be the key step, obtaining a mesomeric structure responsible for the formation of both products.
N-Heterocyclic Carbene-Catalyzed Annulation of Ylides with Ynals: Direct Access to α-Pyrones
Lang, Ming,Jia, Qianfa,Wang, Jian
supporting information, p. 2427 - 2430 (2018/09/10)
We herein report an N-Heterocyclic Carbene (NHC)-catalyzed annulation of ylides with ynals that provides an efficient protocol to make 4,6-disubstituted α-pyrones. This method affords a variety of α-pyrones in good to high yields as well as broad substrat
Preparation of 4,6-Disubstituted α-Pyrones by Oxidative N-Heterocyclic Carbene Catalysis
Bera, Srikrishna,Studer, Armido
, p. 121 - 126 (2016/12/24)
An efficient synthesis of 4,6-disubstituted α-pyrones employing redox activation of enals using N-heterocyclic carbene catalysis is reported. The strategy uses aroyl-substituted nitromethanes and enals as substrates and reactions proceed through an additi
REACTIONS OF AROYLPHENYLACETYLENES WITH ACTIVE METHYLENE-CONTAINING COMPOUNDS
Fouli, F. A.,Basyouni, M. N.
, p. 297 - 302 (2007/10/02)
Aroylphenylacetylenes (Ia-c) react with ethyl cyanoacetate and ethyl acetoacetate in the presence of sodium ethoxide to give the corresponding 3-cyano-4,6-diaryl-2H-pyran-2-ones (IIIa-c) and 4,6-diaryl-2H-pyran-2-ones (IVa-c), respectively.On the other ha
