26480-95-5Relevant academic research and scientific papers
Selective inhibitors of the protein tyrosine phosphatase SHP2 block cellular motility and growth of cancer cells in vitro and in vivo
Grosskopf, Stefanie,Eckert, Chris,Arkona, Christoph,Radetzki, Silke,B?hm, Kerstin,Heinemann, Udo,Wolber, Gerhard,Von Kries, Jens-Peter,Birchmeier, Walter,Rademann, J?rg
, p. 815 - 826 (2015)
Selective inhibitors of the protein tyrosine phosphatase SHP2 (src homology region 2 domain phosphatase; PTPN11), an enzyme that is deregulated in numerous human tumors, were generated through a combination of chemical synthesis and structure-based ration
