264881-21-2Relevant articles and documents
Deoxyribonucleoside cyclic N-acylphosphoramidites as a new class of monomers for the stereocontrolled synthesis of oligothymidylyl-and oligodeoxycytidylyl- phosphorothioates
Wilk, Andrzej,Grajkowski, Andrzej,Phillips, Lawrence R.,Beaucage, Serge L.
, p. 2149 - 2156 (2000)
A simple and straightforward synthesis of the pyrimidine 2'- deoxyribonucleoside cyclic Nacylphosphoramidites R(p)-1 and Sp-1 is described. Specifically, (±)-2-amino-1-phenylethanol 2 was chemoselectively N-acylated to 4 by treatment with ethyl fluoroacet