26502-95-4Relevant academic research and scientific papers
Kinase inhibitors
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Page/Page column 46-47, (2008/06/13)
Compounds, pharmaceutical compositions, kits and methods are provided for use with kinases that comprise a compound of the formula: wherein R1, R2, R3, Q, U, V, W, X, and Y are as defined herein.
Solid-phase synthesis of substituted pyrazolones from polymer-bound β-keto esters
Tietze, Lutz F.,Evers, Holger,Hippe, Thomas,Steinmetz, Adrian,T?pken, Enno
, p. 1631 - 1634 (2007/10/03)
Polymer-bound acetoacetate 3 was γ-mono- and γ-dialkylated, as well as α-monoalkylated, to give 6, 9, and 13, respectively. Treatment with hydrazine or substituted hydrazines followed by thermal or acidic cyclizing cleavage yielded the pyrazolones 17a-dd in a purity of >90%.
Solid-phase synthesis of polymer-bound β-ketoesters and their application in the synthesis of structurally diverse pyrazolones
Tietze, Lutz F.,Steinmetz, Adrian,Balkenhohl, Friedhelm
, p. 1303 - 1306 (2007/10/03)
An efficient solid-phase synthesis of different polymer-bound β-ketoesters 7 is described using readily available acid chlorides 1 and haloalkanes 6 as building blocks. The corresponding pyrazolones 9 and 10 were obtained by mild acid catalyzed reaction with phenylhydrazine or by treatment with hydrazine under cyclisation and cleavage from the resin in high purity and good yield.
