26503-23-1

Usage

Uses

Used in Pharmaceutical Industry:
2-Methyl-4,5,6,7-tetrahydro-2H-indazol-3-amine is used as a building block for the synthesis of various drugs and organic compounds. Its unique structure and properties contribute to the development of diverse molecules with potential biological activity, making it a valuable component in medicinal chemistry research.
Used in Chemical Industry:
In the chemical industry, 2-Methyl-4,5,6,7-tetrahydro-2H-indazol-3-amine serves as an important intermediate for the production of a wide range of organic compounds. Its versatile nature allows for its incorporation into various chemical processes, enhancing the synthesis of molecules with specific applications and properties.

Upstream product

• 4513-77-3 2-cyanocyclohexanone 
• 60-34-4 methylhydrazine 
• 32064-64-5 methylhydrazine oxalic acid salt 

Downstream Products

• 1353570-03-2 N-(2-methyl-4,5.6,7-tetrahydro-2H-indazol-3-ylcarbamothioyl)benzamide 
• 1353570-27-0 C₂₂H₂₄N₆OS 
• 1353570-26-9 C₂₁H₂₁FN₆S 

Relevant academic research and scientific papers

Design and synthesis of aminothiazole modulators of the gamma-secretase enzyme

The design and construction of a series of novel aminothiazole-derived γ-secretase modulators is described. The incorporation of heterocyclic replacements of the terminal phenyl D-ring of lead compound 1 was conducted in order to align potency with favorable drug-like properties. γ-Secretase modulator 28 displayed good activity for in vitro inhibition of Aβ42, as well as substantial improvement in ADME and physicochemical properties, including aqueous solubility. Pharmacokinetic evaluation of compound 28 in mice revealed good brain penetration, as well as good clearance, half-life, and volume of distribution which collectively support the continued development of this class of compounds.

9H-PYRIMIDO[4,5-B]INDOLES AND RELATED ANALOGS AS BET BROMODOMAIN INHIBITORS

The present disclosure provides substituted 9H-pyrimido[4,5-b]indoles and 5H-pyrido[4,3-b]indoles and related analogs represented by Formula I: and the pharmaceutically acceptable salts, hydrates, and solvates thereof, wherein R1a, A, B1, B2, G, X1, Y1, Y2, and Y3 are as defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a condition or disorder responsive to inhibition of BET bromodomains. Compounds of the present disclosure are especially useful for treating cancer.

COMPOUNDS AND USES THEREOF IN MODULATING LEVELS OF VARIOUS AMYLOID BETA PEPTIDE ALLOFORMS

The invention provides a novel compound having a structure corresponding to Formula (I): (A)-(B)-(C)-(D) or a pharmaceutically acceptable salt or prodrug thereof and methods for using them.

Studies on 3'-quaternary ammonium cephalosporins - III. Synthesis and antibacterial activity of 3'-(3-aminopyrazolium)cephalosporins

The synthesis and in vitro antibacterial activity of 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyiminoacetamido] cephalosporins bearing N-mono or dialkyl and carbamoyl aminopyrazolium, and five- or six-membered rings fused to the 3-aminopyrazolium methyl groups at the 3-position, are described. Aminopyrazolium methyl cephalosporins (23e, f, i), with fused saturated and unsaturated rings were especially effective against Staphylococcus strains compared to 3-amino-2-methylpyrazolium methyl cephalosporin (1). Among the cephalosporins prepared in this work, 7β-[(Z)-2-(2-aminothiazol-4-yl)-2-methoxyimino acetamidol-3-(4,5,6,7-tetrahydro-1-pyrazolo[1,5-a] pyrimidinio)methyl-3-cephem-4-carboxylate (23f) showed a good balance of antibacterial activity against both Gram-positive bacteria including Staphylococcus aureus and Gram-negative bacteria including P. aeruginosa. An imidazopyrazolium group at the 3-position in, for example, cephalosporin (23i) was particularly effective for improving antibacterial activity against MRSA.