265118-48-7

Basic information

• Product Name: N-(3-aminopropyl)-4-(3-methyl-5-oxo-2-pyrazolin-1-yl)benzamide
• Synonyms: N-(3-aminopropyl)-4-(3-methyl-5-oxo-2-pyrazolin-1-yl)benzamide
• CAS NO: 265118-48-7
• Molecular Weight: 274.323
• Mol File: 265118-48-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(3-aminopropyl)-4-(3-methyl-5-oxo-2-pyrazolin-1-yl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(3-aminopropyl)-4-(3-methyl-5-oxo-2-pyrazolin-1-yl)benzamide(265118-48-7)
• EPA Substance Registry System: N-(3-aminopropyl)-4-(3-methyl-5-oxo-2-pyrazolin-1-yl)benzamide(265118-48-7)

Safety Data

• Hazardous Substances Data: 265118-48-7(Hazardous Substances Data)

Upstream product

• 60875-16-3 4-(3-methyl-5-oxo-2-pyrazolin-1-yl)benzoic acid 

Relevant articles and documents

SH2-directed ligands of the Lck tyrosine kinase

Two separate libraries, prepared via parallel synthesis, were employed to identify low-molecular-weight SH2-targeted ligands for the Lck tyrosine protein kinase. These libraries were constructed to furnish non-amino acid analogues of the (1) Glu-Glu and (2) Ile residues of the Lck SH2 domain peptide ligand Ac-pTyr-Glu-Glu-Ile-amide. The lead compound acquired in this study exhibits a dissociation constant for the Lck SH2 domain that is comparable to that displayed by Ac-pTyr-Glu-Glu-Ile-amide. These results demonstrate that the standard amino acid residues Glu-Glu-Ile can be completely replaced with non-amino acid moieties without loss of SH2 affinity.