26518-20-7

Upstream product

• 23044-17-9 2,4,2',4'-tetrabromo[3,3']bithiophenyl 
• 35070-39-4 2,4,5,2',4',5'-hexabromo[3,3']bithiophenyl 
• 26554-55-2 4,4'-dibromo-2,2'-diformyl-3,3'-bithienyl 
• 3172-56-3 3,3'-bithiophene 

Relevant academic research and scientific papers

Enatioselective Chalcogeno-Baylis-Hillman reaction of arylaldehydes with MVK and acrylates catalyzed by chiral thiepin-TiCl4 complex

In a rational chiral molecular design of chalcogenides, optically active thiepin with C2-symmetric chirality was synthesized from commercially available thiophene. Then enatioselective Chalcogeno-Baylis-Hillman reactions of arylaldehydes with methyl vinyl ketone (MVK) and acrylates were investigated in the presence of thiepin-Lewis acid complex. Finally, up to 64% ee was achieved in the presence of 0.2 equiv. of (S)-thiepin at 20°C. Enatioselective Chalcogeno-Baylis-Hillman reactions between benzaldehydes and acrylates were investigated in the presence of chiral thiepin-Lewis acid complex. Finally, up to 64% ee was achieved in the presence of 0.2 equiv. of (S)-thiepin at 20°C. Copyright