CASPASE-9, a member of the caspase family of proteases, is integral to the induction of apoptosis, or programmed cell death. Its activation is facilitated by the apoptosome, a protein complex that assembles in response to cellular stress. Once activated, CASPASE-9 initiates the apoptotic cascade by cleaving and activating downstream effector caspases. The regulation of CASPASE-9 is complex, involving interactions with other proteins and post-translational modifications. Its dysregulation is associated with diseases such as cancer and neurodegenerative disorders, highlighting its significance as a therapeutic target.
265294-58-4
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Basic information
- Product Name: CASPASE-9
- Synonyms: ICE-LAP6;FULL-LENGTH CASPASE-9;CASPASE-9;CASPASE-9 (HUMAN) (ACTIVE) (RECOMBINANT);CASPASE-9 HUMAN, RECOMBINANT;CASPASE-9, HUMAN;CASPASE 9 PROTEIN;CASPASE-9, HUMAN, RECOMBINANT, E COLI
- CAS NO:265294-58-4
- Molecular Formula:
- Molecular Weight: 0
- EINECS: N/A
- Product Categories: N/A
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Chemical Properties
- Melting Point: N/A
- Boiling Point: N/A
- Flash Point: N/A
- Appearance: /
- Density: N/A
- Refractive Index: N/A
- Storage Temp.: -70°C
- Solubility: N/A
- CAS DataBase Reference: CASPASE-9(CAS DataBase Reference)
- NIST Chemistry Reference: CASPASE-9(265294-58-4)
- EPA Substance Registry System: CASPASE-9(265294-58-4)
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Safety Data
- Hazard Codes: N/A
- Statements: N/A
- Safety Statements: N/A
- WGK Germany:
- RTECS:
- HazardClass: N/A
- PackingGroup: N/A
- Hazardous Substances Data: 265294-58-4(Hazardous Substances Data)
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265294-58-4 Usage
Uses
Used in Pharmaceutical Industry:CASPASE-9 is used as a therapeutic target for the development of drugs aimed at modulating apoptosis. Its role in the apoptotic pathway makes it a promising candidate for treating diseases where apoptosis is dysregulated, such as cancer and neurodegenerative disorders.
Used in Research Applications:
CASPASE-9 is utilized as a research tool for studying the molecular mechanisms of apoptosis. It aids in understanding the complex interactions and regulatory processes involved in programmed cell death, which is crucial for advancing knowledge in cell biology and disease pathology.
Used in Drug Screening and Development:
CASPASE-9 serves as a biomarker in drug screening processes to identify compounds that can modulate its activity. This is vital for developing new therapeutics that can either activate or inhibit CASPASE-9, depending on the disease context, to restore normal apoptotic function.
Used in Diagnostics:
CASPASE-9 levels or activity can be measured as a diagnostic indicator of diseases associated with dysregulation of apoptosis. Monitoring its status can help in disease prognosis, treatment response evaluation, and personalized medicine approaches.
Used in Biomarker Discovery:
CASPASE-9 may be explored as a potential biomarker for early detection or risk assessment of diseases where its activity is implicated. Identifying changes in CASPASE-9 expression or function could lead to new diagnostic strategies and preventive measures.
Check Digit Verification of cas no
The CAS Registry Mumber 265294-58-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,5,2,9 and 4 respectively; the second part has 2 digits, 5 and 8 respectively.Calculate Digit Verification of CAS Registry Number 265294-58:
(8*2)+(7*6)+(6*5)+(5*2)+(4*9)+(3*4)+(2*5)+(1*8)=164
164 % 10 = 4
So 265294-58-4 is a valid CAS Registry Number.
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CASPASE-9
