265309-32-8Relevant academic research and scientific papers
The design, synthesis and activity of non-ATP competitive inhibitors of pp60(c-src) tyrosine kinase. Part 1: Hydroxynaphthalene derivatives
Marsilje, Thomas H.,Milkiewicz, Karen L.,Hangauer, David G.
, p. 477 - 481 (2000)
A series of hydroxynaphthalene pp60(c-src) non-peptide inhibitors was designed, using the crystal structure of the insulin receptor tyrosine kinase as a qualitative model, to target the peptide substrate binding site. Representative inhibitors were shown to bind non-competitively with respect to ATP. (C) 2000 Elsevier Science Ltd. All rights reserved.
Kinase inhibitors
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Page/Page column 23, (2010/11/08)
The present invention provides a method for identifying inhibitors of protein kinases. Methods are also provided for inhibiting protein kinase activity. Specific non-peptide protein tyrosine kinase inhibitors are provided. The protein kinases produced usi
