265311-80-6Relevant articles and documents
Bicyclic compositions and methods for modulating a kinase cascade
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Page/Page column 136-138, (2008/06/13)
The invention relates to compounds and methods for modulating one or more components of a kinase cascade.
The design, synthesis and activity of non-ATP competitive inhibitors of pp60(c-src) tyrosine kinase. Part 2: Hydroxyindole derivatives
Milkiewicz, Karen L.,Marsilje, Thomas H.,Woodworth Jr., Richard P.,Bifulco Jr., Neil,Hangauer, Matthew J.,Hangauer, David G.
, p. 483 - 486 (2007/10/03)
As part of continuing effort to identify novel scaffolds that inhibit the pp60(c-src) protein tyrosine kinase, a series of hydroxyindole amides was rationally designed and synthesized. The most potent derivative was found to bind non-competitively with respect to ATP. (C) 2000 Elsevier Science Ltd. All rights reserved.