265312-55-8

Basic information

• Product Name: 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE
• Synonyms: 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE;RYUVIDINE;Cdk4 Inhibitor III
• CAS NO: 265312-55-8
• Molecular Formula: C15H13N2O2S
• Molecular Weight: 284.33
• Mol File: 265312-55-8.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 463.8°C at 760 mmHg
• Flash Point: 234.3°C
• Appearance: /
• Density: 1.416g/cm³
• Vapor Pressure: 8.83E-09mmHg at 25°C
• Refractive Index: 1.707
• Storage Temp.: Store at +4°C
• PKA: -1.63±0.20(Predicted)
• CAS DataBase Reference: 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE(265312-55-8)
• EPA Substance Registry System: 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE(265312-55-8)

Safety Data

• Hazardous Substances Data: 265312-55-8(Hazardous Substances Data)

Usage

Uses

Ryuvidine is an antifungal agent used against pathogenic fungi.

General Description

A cell-permeable dioxobenzothiazole compound that acts a selective Cdk4 inhibitor (IC50 = 6.0 μM for Cdk4/D1 and >200 μM for Cdk2/A). Exhibit better cytotoxic potential against cancer cells (IC50 = 0.61, 1.08, 0.30, and 1.21 μg/ml against A 549, Col 1, HL-60, and HepG2 tumor cells, respectively) than Cisplatin (Cat. No. 232120).

Biological Activity

Cyclin-dependent kinase (cdk) 4 inhibitor (IC 50 = 6.0 μ M at cdk4/cyclin D1) that displays > 33-fold selectivity over cdk2 (IC 50 > 200 μ M at cdk2/cyclin A). Cytotoxic against a range of human cancer cells (IC 50 values are 0.30, 0.61, 1.08 and 1.21 μ g/mL for HL-60, A549, Col 1 and HepG2 cells respectively).

Biochem/physiol Actions

Cell permeable: yes

InChI:InChI=1/C15H12N2O2S/c1-8-3-5-10(6-4-8)17-11-7-12(18)15-13(14(11)19)16-9(2)20-15/h3-7,17H,1-2H3