26539-38-8

Usage

Structure

Quinolinone ring with an amino group attached at the 1-position

Type

Chemical compound

Derivative of

Quinolinone

Synthesis

Can be synthesized from 2(1H)-quinolinone

Pharmaceutical Applications

Studied for potential use in antitumor and antiviral drugs

Additional Properties

Exhibits antioxidant and anti-inflammatory properties

Utilization in Organic Chemistry

Used as a building block for the synthesis of various heterocyclic compounds and drugs

Upstream product

• 120332-75-4 1-amino-2-cyanoquinolinium perchlorate 
• 1436-43-7 quinoline-2-carbonitrile 
• 91-64-5 coumarin 

Downstream Products

• 78258-79-4 N-allyl-N-(1,2-dihydro-2-oxoquinolin-1-yl)-4-chlorobenzenesulphenamide 
• 73683-10-0 1-(dibenzylamino)quinolin-2(1H)-one 
• 59-31-4 2-quinolone 
• 73683-06-4 N-benzyl N-(1,2-dihydro-2-oxo-1-qunolil)glycin 
• 73683-05-3 ethyl N-benzyl N-(1,2-dihydro-2-oxo-1-qunolil)glycinate 
• 78034-54-5 [Benzyl-(2-oxo-2H-quinolin-1-yl)-amino]-acetic acid; compound with (S)-1-phenyl-ethylamine 
• 78034-56-7 (S)-(6-Methoxy-quinolin-4-yl)-((1S,2S,4S,5R)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol; compound with [benzyl-(2-oxo-2H-quinolin-1-yl)-amino]-acetic acid 
• 73683-06-4 [Benzyl-(2-oxo-2H-quinolin-1-yl)-amino]-acetic acid 
• 73683-06-4 [Benzyl-(2-oxo-2H-quinolin-1-yl)-amino]-acetic acid 

Relevant academic research and scientific papers

Cytotoxicity, antioxidant, and antimicrobial activities of novel 2-quinolone derivatives derived from coumarin

Coumarins are important and useful compounds with diverse pharmacological properties. New coumarin derivatives namely N-aminoquinoline-2-one 1, 1-((4-hydroxy-6-methyl-2-oxo-2H-pyran-3-yl)methyleneamino)quinolin-2(1H)-one 2 and 1,10-(1E,10E)-(1,4-phenylenebis(methan-1-yl-1-ylidene))bis(azan-1-yl-1- ylidene) diquinolin-2(1H)-one 3, were synthesized and characterized by UV-Vis, FTIR, and NMR spectra in addition of elemental analysis. The synthesized compounds (2 and 3) show considerable anticancer activity against HEp-2 cell line. Synthesized compounds (2 and 3) were tested against selected types of microbial organisms and showed significant activities. The free-radical scavenging activity of synthesized compounds (2 and 3) have been determined by their interaction with the stable freeradical 1,1-diphenyl-2-picrilhydrazyl (DPPH) and all the compounds have shown encouraging antioxidant activities. Springer Science+Business Media B.V. 2011.

A new method for aziridination of olefinic esters

A new method for the preparation of substituted 1-(2-oxoquinolin-1-yl)aziridines (Va-e) is described.Specifically, the lead tetraacetate oxidation of N-aminoquinolone brings about the aziridination of olefinic esters by a mechanism similar to the peracid

Selective Dimerizations of Substituted N-Aminopyridinium Salts and Their Benzologues

N-Aminopyridinium salts bearing ester, aroyl, and cyano functions in position 2 as well as their differently annelated benzologues were reacted with hydroxide ion and alkoxides.In the case of ester compounds 1, 3, and 5, transesterification and dimerization reactions were found.Keto salts 7, 13, and 15 showed dimerization reactions coupled with methanolysis.Monocyclic cyano salt 17 gave amino-as-triazinium double salt 20 while the benzologues (21 and 27) showed three different reactions depending on the conditions used: (a) removal of the cyano group (formation of 22 and 28), (b) formation of new fused 1,2,4-triazole derivatives (26 and 29), and (c) formation of tetrazine-fused dimers (24 and 30).All N-amino-3-substituted-isoquinolinium salts (32) resulted in dimerizations retaining the 3-substituent.Comparison of these results showed that reactivity of the N-amino compound is mainly influenced by the nature of the substituents and by the relative position of the fused benzene ring with respect to the N-amino function.