26549-17-7

Usage

Uses

Used in Pharmaceutical Industry:
3β-Hydroxy-D-friedoolean-14-en-28-oic acid is used as a pharmaceutical compound for its inhibitory activity against HIV-1 reverse transcriptase. This property suggests its potential use in the development of antiretroviral drugs to combat HIV-1 infection.
Used in Research and Development:
In the field of research and development, 3β-Hydroxy-D-friedoolean-14-en-28-oic acid serves as a valuable compound for studying the mechanisms of HIV-1 reverse transcriptase inhibition. This can lead to the discovery of new therapeutic strategies and the development of more effective antiretroviral medications.
Used in Natural Products Industry:
As a naturally occurring compound, 3β-Hydroxy-D-friedoolean-14-en-28-oic acid may also be utilized in the natural products industry for the development of health supplements and nutraceuticals that target immune support and overall wellness. However, further research is needed to establish its safety and efficacy in these applications.

InChI:InChI=1/C30H48O3/c1-25(2)16-17-30(24(32)33)15-10-21-28(6)12-8-19-26(3,4)23(31)11-14-27(19,5)20(28)9-13-29(21,7)22(30)18-25/h10,19-20,22-23,31H,8-9,11-18H2,1-7H3,(H,32,33)/t19-,20+,22-,23-,27-,28+,29+,30+/m0/s1

Upstream product

• 28937-85-1 3-O-acetyl aleuritolic acid 
• 28937-85-1 3-acetylaleuritolic acid 
• 29099-34-1 3α-hydroxytaraxer-14-en-28-oic acid 

Relevant academic research and scientific papers

Anti-HIV and NO production inhibition activities of epi-aleuritolic acid derivatives

Fifteen epi-aleuritolic acid derivatives were synthesized and evaluated for anti-HIV activity in 293 T cells and NO production inhibition activity. Of the derivatives, 1, 2, 3, 4, 11, and 13 showed relatively potent anti-HIV activity with EC50 values ranging from 5.80 to 13.30 μM. The most potent compound, 3α-2′,2′-dimethylsuccinic acyl epialeuritolic acid (11), displayed significant anti-HIV activity with an EC50 value of 5.80 μM. Compounds 1, 3, 4, and 11 showed NO inhibition activity, with IC50 values ranging from 3.40 to 7.10 μM and compound 1 inhibited NO production with an IC50 value of 3.40 μM.

ENT-KAURENES AND OLEANANES FROM CROTON LACCIFERUS

Key Word Index-Croton lacciferus; Euphorbiaceae; ent-kauranes; oleananes; insecticidal activity.The roots of Croton lacciferus furnished three ent-kauranoids, two of which are new natural products, and two oleananes.Two of the kauranoids showed moderate insecticidal activity against Aphis craccivora.

Unambiguous structural and nuclear magnetic resonance spectral characterization of two triterpenoids of Maprounea guianensis by two-dimensional nuclear magnetic resonance spectroscopy

It is shown that 1H-13C shift-correlated two-dimensional spectra obtained for polarization transfer via two bond and three-bond 13C-1H coupling can, in conjunction with related experiments, be used to assign unambiguously the molecular skelatons of two of the less common triterpenes, moretenone and 3-acetylaleuritolic acid.It is concluded that this is a technique of considerable generality for assigning structures of triterpenes and is more reliable than alternative approaches such as mass spectral fragmentation patterns.It has the additional benefit of simultaneously providing reliable 13C and 1H spectral assignments for these compounds.