2655-30-3Relevant academic research and scientific papers
Direct Preparation of N-Substituted Pyrazoles from Primary Aliphatic or Aromatic Amines
Gulia, Nurbey,Ma?ecki, Marcin,Szafert, S?awomir
, p. 9353 - 9359 (2021/07/26)
Despite a large number of synthesis procedures for pyrazoles known today, those directly employing primary amines as substrates are rare. Herein, we report an original method for the preparation of N-alkyl and N-aryl pyrazoles from primary aliphatic or aromatic amines as a limiting reagent of the reaction. The protocol utilizes no inorganic reagents and requires a short reaction time, mild conditions, and the use of structurally simple and commercially available starting reagents. During this study, pyrazoles containing a wide variety of N-substituents were obtained using the same procedure for both aliphatic and aromatic amines.
Iridium-Catalyzed Regio- and Enantioselective Borylation of Unbiased Methylene C(sp3)?H Bonds at the Position β to a Nitrogen Center
Du, Rongrong,Liu, Luhua,Xu, Senmiao
supporting information, p. 5843 - 5847 (2021/02/01)
Reported herein is the pyrazole-directed iridium-catalyzed enantioselective borylation of unbiased methylene C?H bonds at the position β to a nitrogen center. The combination of a chiral bidentate boryl ligand, iridium precursor, and pyrazole directing group was responsible for the high regio- and enantioselectivity observed. The method tolerated a vast array of functional groups to afford the corresponding C(sp3)?H functionalization products with good to excellent enantioselectivity.
