26557-33-5Relevant academic research and scientific papers
Synthesis and biological evaluation of benzimidazole-4,7-diones that inhibit vascular smooth muscle cell proliferation
Hong, Sung-Yu,Chung, Kwang-Hoe,You, Hea-Jung,Choi, Ik Hwa,Chae, Mi Jin,Han, Ja-Young,Jung, Ok-Jai,Kang, Soo-Jung,Ryu, Chung-Kyu
, p. 3563 - 3566 (2007/10/03)
A series of 6-arylamino-5-chloro-benzimidazole-4,7-diones were synthesized and tested for their inhibitory activity on the rat aortic smooth muscle cell (RAoSMC) proliferation. Among them, 6-arylamino-5-chloro-2-methyl-benzimidazole- 4,7-diones exhibited potent antiproliferative activity. Benzimidazole-4,7-dione 2c activated SAPK/JNK signaling pathway in the RAoSMCs.
