26560-83-8

Upstream product

• 70461-33-5 2-bromo-4,5-dimethoxybenzaldehyde dimethyl acetal 
• 72430-92-3 4-[(3,4-dimethoxyphenyl)methyl]dihydrofuran-2-one 
• 225516-13-2 6,7-dimethoxy-2-(methoxycarbonyl)-1-(3,4,5-trimethoxyphenyl)naphthalene-3-carboxylic acid 
• 161359-54-2 6,7-dimethoxy-1-(3,4,5-trimethoxy-phenyl)-naphthalene-2,3-dicarboxylic acid dimethyl ester 
• 1027968-88-2 (2-dimethoxymethyl-4,5-dimethoxy-phenyl)-(3,4,5-trimethoxy-phenyl)-methanol 
• 786703-57-9 6,7-Dimethoxy-9-(3,4,5-trimethoxy-phenyl)-3a,4,9,9a-tetrahydro-3H-naphtho[2,3-c]furan-1-one 

Downstream Products

• 161359-58-6 2,3-bis(hydroxymethyl)-6,7-dimethoxy-1-(3,4,5-trimethoxyphenyl)naphthalene 

Relevant academic research and scientific papers

1-arylnaphthalene lignan: A novel scaffold for type 5 phosphodiesterase inhibitor

1-Arylnaphthalene lignan, which had been reported as a PDE4 inhibitor by Iwasaki, was disclosed as a new structural class of PDE5 inhibitors. The structural requirements for potent and specific PDE5 inhibition were revealed in a 1-arylnaphthalene lignan s

Novel selective PDE IV inhibitors as antiasthmatic agents. Synthesis and biological activities of a series of 1-aryl-2,3- bis(hydroxymethyl)naphthalene lignans

A series of 1-aryl-2,3-bis(hydroxymethyl)naphthalene lignans have been synthesized and evaluated for their ability to selectively inhibit PDE IV isolated from guinea pig. Replacement of the 1-phenyl ring by a pyridone ring led to marked improvement of the

Efficient Syntheses of 1-Arylnaphthalene Lignan Lactones and Related Compounds from Cyanohydrins

1-Arylnaphthalene lignan lactones were synthesized in good yields from O-(tert-butyldimethylsilyl)cyanohydrins in two steps based on a conjugate addition-aldol reaction, followed by acid-catalyzed closure to form the naphthalene ring. 4-Hydroxy-1-arylnaph

A Rapid Entry into Podophyllotoxin Congeners: Synthesis of Justicidin B

A facile synthesis of justicidin B is described, as well as related podophyllum lignans by employing Michael Initiated Ring Clousere Strategy followed by desulfurization mediated by nickel-containing complex reducing agent. - Key words: podophyllotoxin, podophyllum lignans, justicidin B., Michael initiated Ring Closure, desulfurization, nickel-containing complex reducing agent.