265643-77-4Relevant academic research and scientific papers
Substances for treatment or relief of pain
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Paragraph 0257; 0258, (2016/01/25)
Disclosed is the use of an inverse agonist for alpha-subunit-containing gamma-aminobutyric acid A receptor in the preparation of a medicine for the prevention, alleviation, or treatment of pain.
An orally bioavailable, functionally selective inverse agonist at the benzodiazepine site of GABAA α5 receptors with cognition enhancing properties
Chambers, Mark S.,Atack, John R.,Carling, Robert W.,Collinson, Neil,Cook, Susan M.,Dawson, Gerard R.,Ferris, Pushpindar,Hobbs, Sarah C.,O'Connor, Desmond,Marshall, George,Rycroft,MacLeod, Angus M.
, p. 5829 - 5832 (2007/10/03)
(3-tert-Butyl-7-(5-methylisoxazol-3-yl)-2-(1-methyl-1H-1,2, 4-triazol-5-ylmethoxy)pyrazolo[1,5-d][1,2,4]triazine (13) has been identified as a functionally selective, inverse agonist at the benzodiazepine site of GABAA α5 receptors. 13 is orall
