265645-69-0Relevant academic research and scientific papers
Synthesis and anticancer evaluation of α-lipoic acid derivatives
Zhang, Shi-Jie,Ge, Qiu-Fu,Guo, Dian-Wu,Hu, Wei-Xiao,Liu, Hua-Zhang
scheme or table, p. 3078 - 3083 (2010/07/18)
α-Lipoic acid derivatives were synthesized and evaluated for their in vitro anticancer activities against NCI-460, HO-8910, KB, BEL-7402, and PC-3 cell lines. The results, for most compounds exhibited dose-dependent inhibitory property and several compounds had good inhibitions at the dose of 100 μg/mL. Compound 17m was further selected for in vivo evaluation against S180 xenograft in ICR mice, which had 24.7% tumor-weight inhibition through intragastric administration of 200 mg/kg of body weight. Moreover, the LD50 in mice for 17m through ig exceeded 1000 mg/kg of body weight.
LIPOIC ACID DERIVATIVES
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Page/Page column 11-12, (2008/12/04)
Lipoic acid derivatives and pharmaceutical formulations containing lipoic acid derivatives are useful in the treatment and prevention of disease characterized by disease cells that are sensitive to lipoic acid derivatives.
