265656-12-0Relevant academic research and scientific papers
A Cu/Pd Cooperative Catalysis for Enantioselective Allylboration of Alkenes
Jia, Tao,Cao, Peng,Wang, Bing,Lou, Yazhou,Yin, Xuemei,Wang, Min,Liao, Jian
, p. 13760 - 13763 (2015)
A cooperative Cu/Pd-catalyzed asymmetric three-component reaction of styrenes, B2(pin)2, and allyl carbonates was reported. This reaction, in the presence of chiral CuOAc/SOP and achiral Pd(dppf)Cl2 catalysts, occurs smoothly with high enantioselectivities (up to 97% ee). The allylboration products, which contain alkene (or diene) unite and alkylboron group, are easily functionalized. The utility of this protocol was demonstrated through the synthesis of an antipsychotic drug, ()-preclamol.
