265658-97-7Relevant academic research and scientific papers
Thermal ene reactions of 3-(alk-2-enyl)benzylamino-2- (methoxycarbonyl)acrolein derivatives leading to 4,5-dihydro-1H-azepines
Noguchi, Michihiko,Yamada, Hisashi,Takamura, Shinji,Okada, Koichi,Kakehi, Akikazu,Yamamoto, Hidetoshi
, p. 1299 - 1307 (2000)
Thermal reaction of 3-(alk-2-enyl)benzylamino-2- (methoxycarbonyl)acrolein derivatives 3 gave 4,5-dihydro-1H-azepines 4 stereoselectively in good yields via an intramolecular carbonyl-ene reaction. Conjugated diene compounds 10 from acroleins 3 also underwent olefin-ene reaction to give azepine derivatives 11. In these azepine-ring formation, the methoxycarbonyl group at the 2-position in 3 facilitated the progress of the reaction more effectively than the cyano group previously reported by us. (C) 2000 Elsevier Science Ltd.
