265661-16-3Relevant academic research and scientific papers
Copper-catalyzed direct oxidative annulation of N-iminopyridinium ylides with terminal alkynes using O2 as oxidant
Ding, Shengtao,Yan, Yuepeng,Jiao, Ning
supporting information, p. 4250 - 4252 (2013/05/22)
The aerobic direct dehydrogenative annulation of N-iminopyridinium ylides with terminal alkynes leading to pyrazolo[1,5-a]pyridine derivatives has been developed.
Synthesis of 2- and 2,3-substituted Pyrazolo[1,5- a ]pyridines: Scope and mechanistic considerations of a domino direct alkynylation and cyclization of n -iminopyridinium ylides using alkenyl bromides, alkenyl iodides, and alkynes
Mousseau, James J.,Bull, James A.,Ladd, Carolyn L.,Fortier, Angelique,Sustac Roman, Daniela,Charette, Andre B.
experimental part, p. 8243 - 8261 (2012/01/03)
Direct functionalization and tandem processes have both received considerable recent interest due to their cost and time efficiency. Herein we report the synthesis of difficult to obtain 2-substituted pyrazolo[1,5-a] pyridines through a tandem palladium-catalyzed/silver-mediated elimination/direct functionalization/cyclization reaction involving N-benzoyliminopyridinium ylides. As such, these biologically important molecules are prepared in an efficient, high-yielding manner, only requiring a two-step sequence from pyridine. Aryl-substituted alkenyl bromides and iodides are effective ylide coupling partners. Mechanistic studies led to the use of terminal alkynes, which extended the scope of the reaction to include alkyl substitution on the unsaturated reactive site. The optimization, scope, and mechanistic considerations of the process are discussed.
Non-imidazole heterocyclic histamine H3 receptor antagonists
Chai, Wenying,Breitenbucher, J. Guy,Kwok, Annette,Li, Xiaobing,Wong, Victoria,Carruthers, Nicholas I.,Lovenberg, Timothy W.,Mazur, Curt,Wilson, Sandy J.,Axe, Frank U.,Jones, Todd K.
, p. 1767 - 1770 (2007/10/03)
Continued exploration of the SAR around the lead imidazopyridine histamine H3 antagonist 1 has led to the discovery of several related series of heterocyclic histamine H3 antagonists. The synthesis and SAR of indolizine, indole and p
