26576-60-3Relevant academic research and scientific papers
Transesterification of trimethyl orthoacetate: An efficient protocol for the synthesis of 4-alkoxy-2-aminothiophene-3-carbonitriles
Venkata Rao,Balakumar,Lakshmi Narayana,Pran Kishore,Rajwinder,Raghuram Rao
supporting information, p. 1274 - 1278 (2013/03/13)
A facile one-pot method is reported for the synthesis of 4-alkoxy-2-aminothiophene-3-carbonitriles. Transesterification of trimethylorthoacetate technique allowed introducing alkoxy substituents into 2-aminothiophene ring system. Diverse alkoxy substituents could be introduced efficiently by using this methodology. Further the synthesis of some of new 4-alkylamino-2-aminothiophenes is also reported.
